The Effect of Moderate-Intensity Aerobic Activity on Pentylenetetrazol-Induced Epileptic Behaviors in Pregnant Mice

Document Type : Original Article (s)

Authors

1 PhD Student in Motor Behavior, School of Physical Education and Sport Sciences, Razi University, Kermanshah, Iran

2 Assistant Professor, School of Physical Education and Sport Sciences, Razi University, Kermanshah, Iran

3 Assistant Professor, Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran

4 Assistant Professor, Department of Biology, School of Sciences, Razi University, Kermanshah, Iran

Abstract

Background: Epilepsy is one of the major and common neurological disorders. It has been observed that physical activity can be a complementary therapy to treat seizures. Nevertheless, studies regarding the effects of physical activity on epilepsy are largely performed on males, and there is little information on the extent of these effects in females, especially during pregnancy; since it appears that seizures during pregnancy have adverse effects on development of the offspring. The present study was designed to investigate the effect of aerobic training during pregnancy on pentylenetetrazol (PTZ)-induced seizure in mice.Methods: The kindled female mice were divided into 4 groups; 1. the pregnant mice treated with pentylenetetrazol between the fourteenth and nineteenth days of pregnancy once in 48 hours, without physical training during the pregnancy; 2. the pregnant mice treated with pentylenetetrazol between the fourteenth and nineteenth days of pregnancy once in 48 hours, with moderate-intensity aerobic training during pregnancy between 1:00 and 3:00 p.m.; 3. the non-pregnant mice treated with pentylenetetrazol in yoked days with pregnant mice group and without physical training; and 4. the non-pregnant mice treated with pentylenetetrazol in yoked days with pregnant mice group with moderate-intensity aerobic training between 1:00 and 3:00 p.m. The seizure activity was measured for half an hour after pentylenetetrazol injection.Findings: The aerobic training reduced seizure severity in female mice; and there was no difference in seizure severity between pregnant and non-pregnant mice.Conclusion: These findings revealed that middle-intensity aerobic training could be a complementary therapeutic strategy to reduce the severity of seizure, especially in pregnancy.

Keywords

References

  1. Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE, et al. ILAE official report: A practical clinical definition of epilepsy. Epilepsia 2014; 55(4): 475-82.
  2. Ablah E, Hesdorffer DC, Liu Y, Paschal AM, Hawley S, Thurman D, et al. Prevalence of epilepsy in rural Kansas. Epilepsy Res 2014; 108(4): 792-801.
  3. Cossa AC, Lima DC, do Vale TG, de Alencar Rocha AK, da GN-M, da Silva Fernandes MJ, et al. Maternal seizures can affect the brain developing of offspring. Metab Brain Dis 2016; 31(4): 891-900.
  4. Pourmotabbed A, Nedaei SE, Cheraghi M, Moradian S, Touhidi A, Aeinfar M, et al. Effect of prenatal pentylenetetrazol-induced kindling on learning and memory of male offspring. Neuroscience 2011; 172: 205-11.
  5. Li Y, Gonzalez P, Zhang L. Fetal stress and programming of hypoxic/ischemic-sensitive phenotype in the neonatal brain: mechanisms and possible interventions. Prog Neurobiol 2012; 98(2): 145-65.
  6. Bromley R, Weston J, Adab N, Greenhalgh J, Sanniti A, McKay AJ, et al. Treatment for epilepsy in pregnancy: Neurodevelopmental outcomes in the child. Cochrane Database Syst Rev 2014; (10): CD010236.
  7. Nakken KO, Loyning A, Loyning T, Gloersen G, Larsson PG. Does physical exercise influence the occurrence of epileptiform EEG discharges in children? Epilepsia 1997; 38(3): 279-84.
  8. Arida RM, de Jesus V, Cavalheiro EA. Effect of physical exercise on kindling development. Epilepsy Res 1998; 30(2): 127-32.
  9. Arida RM, Sanabria ER, da Silva AC, Faria LC, Scorza FA, Cavalheiro EA. Physical training reverts hippocampal electrophysiological changes in rats submitted to the pilocarpine model of epilepsy. Physiol Behav 2004; 83(1): 165-71.
  10. Arida RM, Scorza FA, de Lacerda AF, Gomes da SS, Cavalheiro EA. Physical training in developing rats does not influence the kindling development in the adult life. Physiol Behav 2007; 90(4): 629-33.
  11. Campos DV, Lopim GM, de Almeida VS, Amado D, Arida RM. Effects of different physical exercise programs on susceptibility to pilocarpine-induced seizures in female rats. Epilepsy Behav 2016; 64(Pt A): 262-7.
  12. Rajabzadeh A, Bideskan AE, Fazel A, Sankian M, Rafatpanah H, Haghir H. The effect of PTZ-induced epileptic seizures on hippocampal expression of PSA-NCAM in offspring born to kindled rats. J Biomed Sci 2012; 19: 56.
  13. Gomes FG, Gomes da SS, Cavalheiro EA, Arida RM. Beneficial influence of physical exercise following status epilepticus in the immature brain of rats. Neuroscience 2014; 274: 69-81.
  14. Gomes da SS, de Almeida AA, Fernandes J, Lopim GM, Cabral FR, Scerni DA, et al. Maternal Exercise during Pregnancy Increases BDNF Levels and Cell Numbers in the Hippocampal Formation but Not in the Cerebral Cortex of Adult Rat Offspring. PLoS One 2016; 11(1): e0147200.
  15. Wang N, Liu Y, Ma Y, Wen D. High-intensity interval versus moderate-intensity continuous training: Superior metabolic benefits in diet-induced obesity mice. Life Sci 2017; 191: 122-31.
  16. Gall C, Lauterborn J, Bundman M, Murray K, Isackson P. Seizures and the regulation of neurotrophic factor and neuropeptide gene expression in brain. Epilepsy Res Suppl 1991; 4: 225-45.
  17. Arida RM, Cavalheiro EA, da Silva AC, Scorza FA. Physical activity and epilepsy: proven and predicted benefits. Sports Med 2008; 38(7): 607-15.
  18. Haut SR, Hall CB, Masur J, Lipton RB. Seizure occurrence: precipitants and prediction. Neurology 2007; 69(20): 1905-10.
  19. Hafele CA, Freitas MP, da Silva MC, Rombaldi AJ. Are physical activity levels associated with better health outcomes in people with epilepsy? Epilepsy Behav 2017; 72: 28-34.
  20. Arida RM, Scorza FA, Terra VC, Scorza CA, de Almeida AC, Cavalheiro EA. Physical exercise in epilepsy: what kind of stressor is it? Epilepsy Behav 2009; 16(3): 381-7.
  21. Burghardt PR, Fulk LJ, Hand GA, Wilson MA. The effects of chronic treadmill and wheel running on behavior in rats. Brain Res 2004; 1019(1-2): 84-96.
  22. Brown DA, Johnson MS, Armstrong CJ, Lynch JM, Caruso NM, Ehlers LB, et al. Short-term treadmill running in the rat: what kind of stressor is it? J Appl Physiol (1985) 2007; 103(6): 1979-85.
  23. Tolmacheva EA, Oitzl MS, van LG. Stress, glucocorticoids and absences in a genetic epilepsy model. Horm Behav 2012; 61(5): 706-10.
  24. Ghodrati-Jaldbakhan S, Ahmadalipour A, Rashidy-Pour A, Vafaei AA, Miladi-Gorji H, Alizadeh M. Low- and high-intensity treadmill exercise attenuates chronic morphine-induced anxiogenesis and memory impairment but not reductions in hippocampal BDNF in female rats. Brain Res 2017; 1663: 20-8.
  25. Russo SJ, Nestler EJ. The brain reward circuitry in mood disorders. Nat Rev Neurosci 2013; 14(9): 609-25.
  26. Brancato A, Bregman D, Ahn HF, Pfau ML, Menard C, Cannizzaro C, et al. Sub-chronic variable stress induces sex-specific effects on glutamatergic synapses in the nucleus accumbens. Neuroscience 2017; 350: 180-9.
  27. Henry JF, Sherwin BB. Hormones and cognitive functioning during late pregnancy and postpartum: A longitudinal study. Behav Neurosci 2012; 126(1): 73-85.
  28. Tauboll E, Sveberg L, Svalheim S. Interactions between hormones and epilepsy. Seizure 2015; 28: 3-11.
  29. Moezi L, Hassanipour M, Zaeri M, Ghorbani H, Shafaroodi H. The influence of ovariectomy on anti-convulsant effect of pioglitazone in mice. Pathophysiology 2015; 22(3): 159-63.
  30. Battino D, Tomson T, Bonizzoni E, Craig J, Lindhout D, Sabers A, et al. Seizure control and treatment changes in pregnancy: Observations from the EURAP epilepsy pregnancy registry. Epilepsia 2013; 54(9): 1621-7.
Journal of Isfahan Medical School
Volume 36, Issue 480 - Serial Number 480
March and April 2018
Pages 535-541

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History

  • Receive Date: 23 April 2018
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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