Five-Year Survival Analysis of Renal Transplantation Graft and Affecting Factors

Document Type : Original Article (s)

Authors

1 Assistant Professor, Department of Biostatistics and Epidemiology, School of Public Health AND Research Center for Environmental Determinants of Health (RCEDH), Kermanshah University of Medical Sciences, Kermanshah, Iran

2 MSc Student, Department of Biostatistics and Epidemiology, School of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran

3 Assistant Professor, Department of Biostatistics and Epidemiology, School of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran

4 MSc Student, Department of Statistics, School of Basic Sciences, Shahid Beheshti University, Tehran, Iran

5 Assistant Professor, Department of Nephrology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

Abstract

Background: Renal transplantation is the appropriate and most effective therapeutic strategy for patients with end-stage renal disease. The aim of this study was to determine the five-year survival rate of renal transplantation graft and affecting factors.Methods: A survival analysis study was performed on the data of 756 renal transplants in Kermanshah, Iran, during 2001 to 2012. Kaplan-Meier, Cox regression methods and log-rank tests were used to estimate the graft survival rate and comparison of cumulative survival difference between the groups was done using STATA software.Findings: Via Kaplan-Meier method, the estimated survival rate of grafts at six months and one, three and five years were 89.0, 87.4, 80.0 and 75.0 percent, respectively. Cox regression model showed that the variables of kinship, donor and recipient sex, and after-surgery creatinine and hemoglobin levels were significantly associated with graft survival rate.Conclusion: The five-year survival rate was 75.0% for renal transplants in the studied center, does not seem satisfactory compared with reported rates of major transplant centers.

Keywords

References

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Journal of Isfahan Medical School
Volume 32, Issue 283 - Serial Number 283
March and April 2014
Pages 550-557

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History

  • Receive Date: 30 July 2013
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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