Genetic Thromboembolic Risk Factors Associated with Deep Vein Throm-bosis in a Iranian Population

Document Type : Original Article (s)

Authors

1 Resident, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

2 Assistant Professor, Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan Cardiology Research Center, Isfahan, Iran.

3 Associate Professor, Department of Neurology, School of Medicine and Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

4 Assistant Professor, Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

5 Professor, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Abstract

 Background: The development of venous thromboembolism is influenced by a variety of genetic and environmental risk factors. A few studies have ascertained whether thrombophilic defects are risk factors for venous thromboembolism in Middle East and Iranian populations or not.Methods: We conducted a case-control study involving 66 consecutive patients with deep vein thrombosis without immobility and 66 healthy controls from the Al-Zahra Hospital in Isfahan, Iran.Finding: The most frequent thrombophilic risk factor for deep vein thrombosis was homocysteine (31/66) (OR = 3.6, 95% CI = (1.66-7.84)). Anticardiolipin antibody was seen in 10.6% (OR =7.71, 95% CI = (0.99-64.55)). There were no significant differences for other risk factor such as Protein S, Protein C, Antithrombin III, Factor V leiden, and Prothrombin mutation. Conclusion: In spite of western studies, Factor V leiden and Prothrombin mutation are rare between Iranian patients. However, homocysteine and anticadiolipin anti bodies are the most frequent risk factors. Screening for Factor V leiden and Prothrombin mutation have not cost benefit and further studies with larger sample size need to detect new mutations and assess the influence of ethnicity on thrombophilia. 

Keywords

References

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Journal of Isfahan Medical School
Volume 28, Issue 114 - Serial Number 114
September and October 2011
Pages 795-800

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History

  • Receive Date: 29 December 2010
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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