The Frequency of Hepatitis E in Renal Transplant Recipients in Isfahan City, Iran, on the Basis of Molecular Evaluation

Document Type : Original Article (s)

Authors

1 Professor, Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Infectious Diseases and Tropical Medicine Specialist, Shahrekord University of Medical Sciences, Shahrekord, Iran

3 Associate Professor, Nosocomial Infections Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

4 Associate Professor, Department of Internal Medicine, School of Medicine AND Kidney Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Hepatitis E virus (HEV) belongs to the family of Hepeviridae and is the sole member of the genus Hepevirus. HEV infection by genotypes 3 and 4 may tend to chronic infection, especially in immunocompromised patients such as liver and renal transplant patients. This study aimed to assess the frequency of HEV infection in kidney transplant recipients.Methods: This was a cross-sectional study on kidney transplant recipients in Isfahan City, Iran, in 2016. 100 renal transplant recipients were randomly selected and reviewed in Alzahra hospital. Blood samples were obtained from 100 eligible patients. Serum samples were screened for HEV RNA by using real-time polymerase chain reaction (PCR).Findings: Mean age of the patients was 48.2 ± 14.2 years and 63% of them were men. Based on molecular evaluation, all off 100 studied patients had negative results for HEV.Conclusion: HEV infection is not an important problem in renal transplant recipient. It is recommended to check the patients with renal transplant for HEV when liver enzyme is elevated and it is not recommended as a routine lab test.

Keywords

References

  1. Boutrouille A, Bakkali-Kassimi L, Cruciere C, Pavio N. Prevalence of anti-hepatitis E virus antibodies in French blood donors. J Clin Microbiol 2007; 45(6): 2009-10.
  2. Nazer M, Darvishi M, Dadashi A. Serologic Prevalence of Hepatitis E in Iran and the Risk of Bioterrorism. Ann Mil Health Sci Res. 2011; 9 (3) :209-17. [In Persian].
  3. Taremi M, Gachkar L, MahmoudArabi S, Kheradpezhouh M, Khoshbaten M. Prevalence of antibodies to hepatitis E virus among male blood donors in Tabriz, Islamic Republic of Iran. East Mediterr Health J 2007; 13(1): 98-102.
  4. Levitsky J, Doucette K. Viral hepatitis in solid organ transplantation. Am J Transplant 2013; 13(Suppl 4): 147-68.
  5. Aggarwal R, Naik S. Epidemiology of hepatitis E: current status. J Gastroenterol Hepatol 2009; 24(9): 1484-93.
  6. Sotoodeh JA, Pourahmad M. Hepatitis E virus and serum level aminotransferases in blood donors. Rep Biochem Mol Biol 2013; 2(1): 48-51.
  7. Dalton HR, Bendall RP, Keane FE, Tedder RS, Ijaz S. Persistent carriage of hepatitis E virus in patients with HIV infection. N Engl J Med 2009; 361(10): 1025-7.
  8. Ollier L, Tieulie N, Sanderson F, Heudier P, Giordanengo V, Fuzibet JG, et al. Chronic hepatitis after hepatitis E virus infection in a patient with non-Hodgkin lymphoma taking rituximab. Ann Intern Med 2009; 150(6): 430-1.
  9. Kamar N, Garrouste C, Haagsma EB, Garrigue V, Pischke S, Chauvet C, et al. Factors associated with chronic hepatitis in patients with hepatitis E virus infection who have received solid organ transplants. Gastroenterology 2011; 140(5): 1481-9.
  10. Hoofnagle JH, Nelson KE, Purcell RH. Hepatitis E. N Engl J Med 2012; 367(13): 1237-44.
  11. Gonzalez Tallon AI, Moreira V, V, Mateos Lindemann ML, Achecar Justo LM. Chronic hepatitis E in an immunocompetent patient. Gastroenterol Hepatol 2011; 34(6): 398-400. [In Spanish].
  12. Kamar N, Selves J, Mansuy JM, Ouezzani L, Peron JM, Guitard J, et al. Hepatitis E virus and chronic hepatitis in organ-transplant recipients. N Engl J Med 2008; 358(8): 811-7.
  13. Buffet C, Laurent-Puig P, Chandot S, Laurian Y, Charpentier B, Briantais MJ, et al. A high hepatitis E virus seroprevalence among renal transplantation and haemophilia patient populations. J Hepatol 1996; 24(1): 122-5.
  14. Ibarra H, Riedemann S, Reinhardt G, Ardiles L, Calvo M, Siegel F. Anti-HEV in dialysis and renal transplant patients in an endemic region in Chile. Clin Nephrol 1998; 50(4): 267-8.
  15. Wedemeyer H, Pischke S, Manns MP. Pathogenesis and treatment of hepatitis e virus infection. Gastroenterology 2012; 142(6): 1388-97.
  16. Chaillon A, Sirinelli A, De MA, Nicand E, d'Alteroche L, Goudeau A. Sustained virologic response with ribavirin in chronic hepatitis E virus infection in heart transplantation. J Heart Lung Transplant 2011; 30(7): 841-3.
  17. Peron JM, Bureau C, Poirson H, Mansuy JM, Alric L, Selves J, et al. Fulminant liver failure from acute autochthonous hepatitis E in France: description of seven patients with acute hepatitis E and encephalopathy. J Viral Hepat 2007; 14(5): 298-303.
  18. Assarehzadegan MA, Shakerinejad G, Amini A, Rezaee SA. Seroprevalence of hepatitis E virus in blood donors in Khuzestan Province, southwest Iran. Int J Infect Dis 2008; 12(4): 387-90.
  19. Ataei B, Nokhodian Z, Javadi AA, Kassaian N, Shoaei P, Farajzadegan Z, et al. Hepatitis E virus in Isfahan Province: a population-based study. Int J Infect Dis 2009; 13(1): 67-71.
  20. Saffar MJ, Farhadi R, Ajami A, Khalilian AR, Babamahmodi F, Saffar H. Seroepidemiology of hepatitis E virus infection in 2-25-year-olds in Sari district, Islamic Republic of Iran. East Mediterr Health J 2009; 15(1): 136-42.
  21. Alizadeh AH, Ranjbar M, Ansari S, MirArab A, Alavian SM, Mohammad K, et al. Seroprevalence of hepatitis B in Nahavand, Islamic Republic of Iran. East Mediterr Health J 2006; 12(5): 528-37.
  22. Rostamzadeh KZ, Sepehrvand N, Masudi S. Seroprevalence of hepatitis E among Iranian renal transplant recipients. Hepat Mon 2011; 11(8): 646-51.
  23. Pischke S, Stiefel P, Franz B, Bremer B, Suneetha PV, Heim A, et al. Chronic hepatitis e in heart transplant recipients. Am J Transplant 2012; 12(11): 3128-33.
  24. Haagsma EB, Niesters HG, van den Berg AP, Riezebos-Brilman A, Porte RJ, Vennema H, et al. Prevalence of hepatitis E virus infection in liver transplant recipients. Liver Transpl 2009; 15(10): 1225-8.
  25. Parsa R, Adibzadeh S, Behzad BA, Farhadi A, Yaghobi R, Rafiei Dehbidi GR, et al. Detection of Hepatitis E Virus Genotype 1 Among Blood Donors From Southwest of Iran. Hepat Mon 2016; 16(6): e34202.
Journal of Isfahan Medical School
Volume 35, Issue 448 - Serial Number 448
July and August 2017
Pages 1283-1288

Files

History

  • Receive Date: 18 October 2017
  • Revise Date: 02 November 2024
  • Accept Date: 06 April 2022

Share

How to cite

Statistics