The Association of Thrombosis-Related Factors Polymorphisms and the Risk of Uterine Myoma

Document Type : Original Article (s)

Authors

1 Department of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran

2 Assistant Professor, Cellular and Molecular Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3 Assistant Professor, Department of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran

4 Associate Professor, Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract

Background: Myomas are benign monoclonal tumors of the smooth muscle cells of the endometrium. Venous thromboembolism (VTE) is a common complication of cancers; however, their contributions to thrombotic tendency in patients with cancer have conflicting results. The present study was designed to investigate the relationship of the polymorphisms of clotting factor gene and the risk of uterine myoma.Methods: In this study, three selected polymorphisms of thrombotic factors gene were evaluated using amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) method. We focused on the prevalence of PTH G20210A, FGB G-455A and PAI-1 4G/5G polymorphisms in 50 women with clinically diagnosed uterine myoma and 50 healthy controls. The data were analyzed using chi-square test via SPSS19 software.Findings: The PTH (rs1799963), FGB (rs1800790) and PAI-1 (rs1799889) polymorphisms were not correlated with an increased risk of uterine myoma in the study population (P > 0.05).Conclusion: We observed no associations of the investigated polymorphisms with the risk of uterine myoma in studied population.

Keywords

References

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Journal of Isfahan Medical School
Volume 32, Issue 303 - Serial Number 303
July and August 2014
Pages 1594-1604

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History

  • Receive Date: 22 April 2014
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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