Risk Factors Associated with Aspiration Pneumonia among the Patients with Drug Intoxication

Document Type : Original Article (s)

Authors

1 Professor, Department of Clinical Toxicology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Assistant Professor, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

4 Assistant Professor, Department of Community Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Poisoning is one of the serious underlying causes of loss of consciousness. Due to the relative lack of preserving factors of respiratory tract, risk of aspiration pneumonia would be increased. We evaluated factors associated with aspiration pneumonia in patients admitted with acute drug intoxication.Methods: A retrospective cohort randomized study conducted on 206 patients admitted at clinical toxicology department. Based on the diagnosis of aspiration pneumonia, patients were divided into two groups of with and without aspiration pneumonia. Binary logistic regression analysis was performed for aspiration pneumonia prediction factors.Findings: Age, gender, ingested toxin, vital sign, the level of consciousness on admission, gastric lavage, past history of smoking and pulmonary disease, seizure, vomiting, endotracheal intubation, and length of hospital stay were significantly different in patients with and without aspiration pneumonia (P < 0.05). Among variables, endotracheal intubation [odds ratio (OR) = 50.83], seizure (OR = 22.19), gender (men, OR = 3.49), pulse rate (OR = 1.03), age (OR = 1.03), and vomiting (OR = 0.20) were determinants factors in aspiration pneumonia.Conclusion: Seizure, age, male gender, pulse rate, vomiting, and endotracheal intubation should be considered as important factors in predicting aspiration pneumonia when managing poisoning cases.

Keywords

References

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Journal of Isfahan Medical School
Volume 36, Issue 479 - Serial Number 479
March and April 2018
Pages 510-516

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History

  • Receive Date: 07 May 2018
  • Revise Date: 01 November 2024
  • Accept Date: 06 April 2022

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