BackgroundSmoking is one of most important problems of health situation in the entire world. Oxidant materials in cigarette have a positive role in increasing risk of atherosclerosis and other maleffects of such ingredients. The objective of this study is to evaluate the effects of cigarette smoking on lipid peroxidation, values of HbA1C, quantitative CRP and conjugated CRP and conjugated dienes (CDs) in smoker and non-smoker men. MethodsIn this descriptive analytical study, fifty healthy male smokers and fifty male non-smokers were selected by a convenient sampling method. The smokers had history of at least 6 pack/year cigarette (about 10-20 cigarette/day) uses. Measurement of fasting plasma glucose, quantitative CRP, HbA1C, lipid peroxidants, conjugated dienes, cholesterol and triglyceride were done for all patients. FindingsStudy showed the values of the HbA1C, Lipid oxidants and CRP were significantly higher in the smokers than non-smokers. There was a positive relation between duration of smoking and the number of cigarettes smoked per day and HbA1C. There was also correlation between fasting blood sugar and the number of smoked cigarette per day and this correlation was significant. ConclusionOur results confirm the effects of smoking on lipid oxidation, hemoglobulin glycation and CRP as possible contributor of atherosclerosis, although further studies are recommended to verify the exact mechanisms. Key words: Cigarette Smoking, Lipid peroxidation, HbA1C, CRP, Conjugated dienes