Comparing Side effects of CinnoVex with Avonex in Relapsing Remitting Multiple Sclerosis Patients

Document Type : Original Article(s)

Authors

1 Professor, Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan

2 Medical Student, School of Medicine, Isfahan University of Medical Sciences, Isfahan

3 Assistant Professor, Department of Neurology, School of Medicine, Najaf Abad Azad University, Isfahan

Abstract

BackgroundMultiple Sclerosis (MS) is a demyelinating disease of central nervous system with an unknown etiology. Beta-Interferon is now widely used for treatment of MS which is believed to slow down the disease progression. This study was designed to compare the side-effects of Avonex and the Iranian 1-a Beta-Interferon, Cinnovex, which are biosimilars. MethodsThis was a clinical trial study in which fifty one MS patients were recruited from the neurology departments of Al-Zahra and Shariati hospitals in 2007. Twenty one patients were receiving Avonex and thirty patients were receiving Cinnovex. These patients were followed for 3 months to compare the side-effects of the drugs between two groups. FindingsThe most prevalent side effect observed was influenza like symptoms in all patients receiving Avonex and in 83.3% of patients receiving Cinnovex. There were no cases of seizure or diarrhea in any of groups. In this study, there were no significant differences between two groups in respect to experienced side-effects. ConclusionThis study with a short duration follow-up of 3 months demonstrated no significant differences between the two groups in case of experienced side-effects. Key words: CinnoVex, Avonex, side effects, treatment, Interferon beta 1-a, multiple sclerosis
Journal of Isfahan Medical School
Volume 27, Issue 93 - Serial Number 93
January and February 2009
Pages 93-101

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History

  • Receive Date: 07 November 2010
  • Revise Date: 02 May 2024
  • Accept Date: 06 April 2022

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