Effectiveness of Prebiotic in Atopic Dermatitis Reduction in 7-24 Months Old Children Living in Isfahan

Document Type : Original Article (s)

Authors

1 Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

2 Professor, Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

3 Assistant Professor, Department of Pediatrics, Alzahra Hospital, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

4 Assistant Professor, Department of Epidemiology and Biostatistic, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

Background: Atopic dermatitis (AD) is a prevalent medical condition in infancy with the prevalency of near 10 to 25% in western countries. Current standard of care for atopic dermatitis can lead to many complications. There is a need for alternative treatments with lower risks of side effects. Recent studies have shown a positive effect of prebiotics in prevention and treatment of the disease. The main objective of this study was to determine whether consumption of prebiotics can reduce the severity of atopic dermatitis in 7-24 months old children in Isfahan.Methods: In a double blind controlled clinical trial study, 70 atopic dermatitis children were divided by simple random sampling into treated group receiving prebiotic (fructooligosaccharid + inulin) and control group receiving placebo (dextrin powder) for 3 months. At the beginning and at the end of intervention, SCORAD test questionnaire was completed for all children by a physician. The collected data were analyzed by SPSS software, using student-t and paired-t tests. P values less than 0.05 were considered statistically significant.Findings: The difference between total SCORAD indices before intervention in the treated and control groups was not statistically significant (53.9 ± 23.6 and 43.4 ± 20.9, respectively). After intervention, these values were reduced in the treated and control groups, but the difference between the means of the two groups was statistically significant (4.3 ± 9.6 and 19.4 ± 13.0, repectively; P < 0.001).Conclusion: Prebiotic substances have positive roles in adjutant treatment of atopic dermatitis. 

Keywords

References

  1. Leung DY. Atopic dermatitis (Atopic eczema). In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, Editors. Nelson Textbook of Pediatrics. Philadelphia: Saunders Company; 2007. p. 970-5.
  2. Leung DY, Eichenfield LF, Boguniewicz M. Atopic Dermatitis. In: Fitzpatrick TB, Wolff K, Goldsmith LA, Katz S, Gilchrest BA, Paller AS, et al, Editors. Fitzpatrick's dermatology in general medicine. Philadelpihai: Mc Grow Hill; 2008. p. 146-8.
  3. James DW, Berger TG, Elston D, Odom RB. Andrewss Diseases of the Skin Clinical Dermatology. 10th ed. Philadelphia: Saunders Elsevier; 2006. p. 69-76.
  4. Ronmark E, Perzanowski M, Platts-Mills T, Lundback B. Four-year incidence of allergic sensitization among schoolchildren in a community where allergy to cat and dog dominates sensitization: report from the Obstructive Lung Disease in Northern Sweden Study Group. J Allergy Clin Immunol 2003; 112(4): 747-54.
  5. Kusel MM, Holt PG, de Klerk N, Sly PD. Support for 2 variants of eczema. J Allergy Clin Im-
  6. munol 2005; 116(5): 1067-72.
  7. Veereman G. Pediatric applications of inulin and oligofructose. J Nutr 2007; 137(11 Suppl): 2585S-9S.
  8. Gallagher ML. The nutrients and their metabolism. In: Mahan LK, Escott-Stump S, editors. Krause's Food & Nutrition Therapy. Philadelphia: Saunders Elsevier; 2008. p. 38-42.
  9. Moro G, Arslanoglu S, Stahl B, Jelinek J, Wahn U, Boehm G. A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age. Arch Dis Child 2006; 91(10): 814-9.
  10. Passeron T, Lacour JP, Fontas E, Ortonne JP. Prebiotics and synbiotics: two promising approaches for the treatment of atopic dermatitis in children above 2 years. Allergy 2006; 61(4): 431-7.
  11. Bruno G, Milita O, Ferrara M, Nisini R, Cantani A, Businco L. Prevention of atopic diseases in high risk babies (long-term follow-up). Allergy Proc 1993; 14(3): 181-6.
  12. Scientific Committee on Food. Additional statement on the use of resistant short chain carbohydrates (oligofructosyl-saccharose and oligogalactosyl-lactose) in infant formulae and in follow-on formula. Proceedings of the European Commission, Health & Consummer Ptotection Directorate-General; 2001 Dec 13-14; Bruxelles, Belgique; 2001. Available from: URL: http://ec. europa.eu/food/fs/sc/scf/out109_en.pdf.: 2001.
  13. Williams HC. On the definition and epidemiology of atopic dermatitis. Dermatol Clin 1995; 13(3): 649-57.
  14. Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis. Dermatology 1993; 186(1): 23-31.
  15. Noverr MC, Huffnagle GB. The 'microflora hypothesis' of allergic diseases. Clin Exp Allergy 2005; 35(12): 1511-20.
  16. Kukkonen K, Savilahti E, Haahtela T, Juntunen-Backman K, Korpela R, Poussa T, et al. Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial. J Allergy Clin Immunol 2007; 119(1): 192-8.
  17. Shibata R, Kimura M, Takahashi H, Mikami K, Aiba Y, Takeda H, et al. Clinical effects of kestose, a prebiotic oligosaccharide, on the treatment of atopic dermatitis in infants. Clin Exp Allergy 2009; 39(9): 1397-403.
Journal of Isfahan Medical School
Volume 28, Issue 113 - Serial Number 113
September and October 2011
Pages 716-724

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History

  • Receive Date: 29 December 2010
  • Revise Date: 06 May 2024
  • Accept Date: 06 April 2022

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