Journal of Isfahan Medical School

Journal of Isfahan Medical School

The Effect of Pentoxyfiline on Hemoglobin and the Dose of Erythropoietin in Anamic Peritoneal Dialysis Patients

Document Type : Original Article(s)

Authors
Mojgan Mortazavi 1
Shiva Seirafian 2
Shahram Taheri 2
Afsoon Emami 2
Fahimeh Samiminia 3
Firoozeh Moinzadeh 4
Afrooz Eshaghian 3
Sayed Hosein Hoseini 5
1 Assistant Professor, Department of Nephrology, Isfahan Kidney Diseases Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Associate Professor, Department of Nephrology, Isfahan Kidney Diseases Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Student of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4 Internal Medicine Resident, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
5 Department of Epidemiology, Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Abstract
Background: Anemia is one of the major problems of dialysis patients The primary mechanism of anemia in these patients is Erythropoietin insufficient production by kidneys. Often, this kind of anemia is caused by inflammatory reactions. A large number of dialysis patients, despite receiving adequate doses of erythropoietin, are anemic. Therefore it seems the use of a pharmaceutical composition that can control the inflammatory reactions is an appropriate strategy. This study was done to investigate the effect of Pentoxyfilline on hemoglobin level and Erythropoietin dose in these patientsMethods: This study was a clinical trial that performed on anemic peritoneal dialysis patients. Study patients were randomized to two groups of 25 person recipients Pentoxyfilline and control groups. The amount of blood hemoglobin and serum albumin, iron, Total Iron Binding Capacity (TIBC), ferritin and Parathormone (PTH) were measured at the beginning and the end of the study. Collected data were analyzed by SPSS software.Finding: 45 patients were studied (20 cases and 25 controls). The results of this study have not shown the significant differences in hemoglobin and serum albumin levels changes between two groups. According to results of this study the change of erythropoietin dose was not significant in both goups.Conclusions: According to the results, conducted another study with higher sample size and longer time for investigation of the effect Pentoxyfilline is recommended.
Keywords
Pentoxyfilline
Peritoneal dialysis
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Journal of Isfahan Medical School
Volume 28, Issue 115 - Serial Number 115
September and October 2011
Pages 974-979

  • Receive Date 02 March 2011
  • Accept Date 06 April 2022