Effect of Melatonin in the Prevention of Post-operative Adhesion Formation in an Experimental Study

Document Type : Original Article (s)

Authors

1 Assistant Professor of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences

2 Assistant of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences

3 Veterinarian, Torabi Nejad Research center, Isfahan University of Medical Sciences

Abstract

Post operative adhesion formation is a very important clinical problem because of its complications such as pain, bowel obstruction, infertility and subsequent intra-operative complications. We aimed to investigate the effects of melatonin (ME), as an agent acting against free radicals, on the prevention of adhesion formation. Background: A number of 39 rats were randomly assigned into three groups of equal number. Serosal injury was created using a standard technique, one group received a single dose of intraperitoneal (IP) ME immediately after injury; a single dose of subcutaneous (SC) ME was given to the second group 30 minutes prior to surgery; but the control group did not received ME. All animals were re-operated 2 weeks after the surgery and the adhesion scores were determined by an examiner blinded to the under experiment groups. Methods: The total score of adhesion reduced significantly in IP and SC groups in comparison to controls (p
Journal of Isfahan Medical School
Volume 25, Issue 87 - Serial Number 87
September and October 2008

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History

  • Receive Date: 17 January 2011
  • Revise Date: 24 April 2024
  • Accept Date: 06 April 2022

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