Journal of Isfahan Medical School

Journal of Isfahan Medical School

The Role of Glucose-Insulin-Potassium in Myocardial Protection during On-Pump Coronary Artery Bypass Graft Surgery

Document Type : Original Article(s)

Authors
Omid Aghadavoudi 1
Sayed Mohammadreza Safavi 1
Azim Honarmand 1
Saeid Pourseirafi 2
1 Associate Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Medical Student, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Background: Glucose-insulin-potassium (GIK) could be protect myocardium from hypoxia by improvement myocites function with providing normal carbohydrate and metabolism of fatty acids. This study reviews the effect of GIK on cardiac function in coronary artery bypass graft(CABG) surgery with cardiopulmonary bypass.Methods: This clinical trial was carried out on 60 patients undergoing elective CABG with ejection fraction lower than 40 percent and age 40-70 years old. Patients were divided in two groups(30 person in each groop): GIK group and control group. Ejection fraction changes after surgery, the frequency of arrhythmia, the frequency of consumption of inotropes, need to shock, need to temporary pacemaker after surgery and mean duration of staying in ICU were compared in the two study groups by student's t-test and χ2.Finding: This study showed that arrhythmia, inotrope use and staying in ICU in case group was lower than the control group (05 / 0> P).Conclusion: According to the results of this study we can be say clearly that the effects of GIK in reducing the incidence of arrhythmia and postoperative inotrope consumption and reduced the duration of satying in ICU is remarkable.
Keywords
Glucose-Insulin-Potassium
Ejection fraction
Arrhythmia
Cardiac Surgery
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Journal of Isfahan Medical School
Volume 28, Issue 120 - Serial Number 120
November and December 2011
Pages 1505-1512

  • Receive Date 19 March 2011
  • Accept Date 06 April 2022