Small Bowel Anastomosis with New Fibrin Glue in Animal Model

Document Type : Original Article (s)

Authors

1 Associate Professor, Department of General Surgery ,School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

2 Resident, Department of General Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

3 Epidemiologist, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

4 Assistant Professor, Department of Pathology, School of Specialize Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.

5 Torabinejad Animal Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Abstract

Background: In many surgical procedures in pelvic and abdomen, gastrointestinal anastomosis has a main role.These days, bowel anastomosis is done with some techniques like handsewn and stapler anastomosis. In some research, the use of fibrin glue in abdomen is convenient, operation time is reduced, and intra abdominal adhesion is lower than standard manner. In this research we evaluated new fibrin glue for small bowel anastomosis in animal model.Methods: In this experimental study, we operated 5 dogs in same race, age and gender. After laparatomy under general anesthesia 5 cm of small intestine resected, then anastomos with new fibrin glue was done. After 15 days, the dogs were reoperated and surgical site was evaluated and then anastomosis was done by handsewn method. PASW version 18 was used for data analysis.Finding: Mean time for anastomosis with fibrin glue was 6:47 and 11:11 for handsewn. Mortality and peritonitis didn’t occur. After second operation there was no any sign of leakage, intraperitoneal inflammation and abscess. In microscopic only one case attachment wasn’t seen in mucosa and submucosal layers but it was occurred in muscular and serosal layers.Conclusion: The mean time of FG anastomosis was shorter than handsewn and the patency of surgical site was favorable beause there was no significant different between diameters of proximal and distal lumens compare whit normal bowel diameter. Our data reveals that we can use FG (that reinforced by nano particles) for reinforcement of GI anastomosis with high safety level, especially in high risk situation.

Keywords

References

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Journal of Isfahan Medical School
Volume 29, Issue 134 - Serial Number 134
March and April 2011
Pages 394-402

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History

  • Receive Date: 23 May 2011
  • Revise Date: 29 April 2024
  • Accept Date: 06 April 2022

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