Hepatits C and B in Blood Transfusion Recipients Indentified at Isfahan Province

Document Type : Original Article(s)

Authors

1 Associate Professor, Department of Gastroenterology, Isfahan Liver Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Resident, Department of Internal Medicine, School of Medicine And Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

3 Epidemiologist, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

4 Architect, Young Researchers Club, Khorasgan Branch, Islamic Azad University, Isfahan, Iran.

5 Associate Professor, Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Abstract

Background: This study was conducted to assess the prevalence of Hepatitis C virus (HCV), Hepatitis B virus (HBV) and Human Immunodeficiency virus (HIV) among hemophilia and thalassemia patients.Methods: This cross-sectional study was conducted from October 2008 to December 2010 in Isfahan, Iran. 1160 adult multi-transfused patients suffering from beta-thalassemia (n = 545) and hemophilia (n = 615) were enrolled in the study. Blood samples were obtained from the patients and were tested for HBs Ag, Anti-HCV Ab and Anti- HIV Ab. Patients with HCV positive underwent genotype determination.Finding: 822 males and 338 females (mean age 22.7 ± 11.5 years, range 1-76 years) were investigated in this study.312 males (57.2%) and 233 (42.8%) females had thalassemia. 511 (83%) males and 104 (17%) females were in hemophilia group. Of the 505 (82.1%) persons with chronic hepatitis in hemophilia patients, 495 (98%) patients were HCV antibody positive and 10 (2%) patients had HBs positive. There were 56 (11%) patients with chronic hepatitis in patients with thalassemia. Of them, 50 (89.2%) patients were HCV antibody positive and 6 (10.8%) patients had HBs positive. None of the thalassemia and hemophilia patients was positive for HIV Ab. HCV genotype 1 was the major genotype among patients.  Conclusion: HCV is a major virus of concern in the multi-transfused patients. The strategies for prevention of HBV and safety of blood products in this respect have indeed been successful. Family History of hepatitis is the major risk factors among patients. 

Keywords

References

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Journal of Isfahan Medical School
Volume 29, Issue 139 - Serial Number 139
March and April 2011
Pages 615-620

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History

  • Receive Date: 20 June 2011
  • Revise Date: 02 May 2024
  • Accept Date: 06 April 2022

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