Evaluation of the Efficacy of Piroxicam Gel in the Control of Pain and Erythema Caused by Fractional Co2 Laser Compared with Lubricant Gel

Document Type : Original Article (s)

Authors

1 Associate Professor, Departement of Dermatoloy, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

2 Resident, Department of Dermatology, School of Medicine And Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran.

3 Associate Professor, Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.

Abstract

Background: Fractional Co2 laser is a good procedure to treat acne scar, surgical scar and senile wrinkles but it is almost painful and if we provide a good pain relief the patient will have a good cooperation during laser, so we can use higher fluence with better results. To determine the safety and efficacy of piroxicam gel in the control of pain and erythema caused by fractional Co2 laser compared with lubricant gel.Methods: In this clinical trial we chose 122 patients who refered to Novin laser clinic for fractional Co2 laser. The patients used gel A (piroxicam gel) on one side of the face and gel B (lubricant gel) on the other side of the face as placebo an hour before laser. To determine pain level we used VAS (Visual analogue scale) score from one point to ten. Each patient scored the pain during, immediately after, 1 hour later and 24 hours after laser. To determine the severity of erythema during, immediately after, 1 hour later and one week after laser we compared the erythema of both side of the face with each other. We also compare the prevalence of Post-inflammatory pigmentation (PIP) after 1 month of laser with both gels. At the end we analyzed the data with SPSS18.Finding: Piroxicam gel can provide better pain relief during laser, immediately after laser and 1 hour later compared with lubricant gel but pain score was the same 24 hours later with both gels. The severity of erythema with both gels was the same during laser, immediately after, 1 hour later and after one week. In fact piroxicam gel has no effect on the erythema caused by fractional Co2 laser.The prevalence of PIP was the same for both gels after one month so piroxicam gel can not prevent PIP caused by fractional Co2 laser.Conclusion: As a result piroxicam gel can use as a safe and effective drug before fractional Co2 laser to decrease the pain but has no effect on erythema and PIP caused by fractional Co2 laser. 

Keywords

References

  1. Hale EK, Sukal S, Chapas AM, Kim KH, Bernstein L, Geronemus G. Fractional carbon dioxide laser resurfacing of photodamage and acne scars . Lasers Surg Med 2007; 39(Suppl 19): 83.
  2. Hasegawa T, Matsukura T, Mizuno Y, Suga Y, Ogawa H, Ikeda S. Clinical trial of a laser device called fractional photothermolysis system for acne scars. J Dermatol 2006; 33(9): 623-7.
  3. Kono T, Chan HH, Groff WF, Manstein D, Sakurai H, Takeuchi M, et al. Prospective direct comparison study of fractional resurfacing using different fluences and densities for skin rejuvenation in Asians. Lasers Surg Med 2007; 39(4): 311-4.
  4. Manstein D, Herron GS, Sink RK, Tanner H, Anderson RR. Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury. Lasers Surg Med 2004; 34(5): 426-38.
  5. Friedman PM, Fogelman JP, Nouri K, Levine VJ, Ashinoff R. Comparative study of the efficacy of four topical anesthetics. Dermatol Surg 1999; 25(12): 950-4.
  6. Hahn IH, Hoffman RS, Nelson LS. EMLA-induced methemoglobinemia and systemic topical anesthetic toxicity. J Emerg Med 2004; 26(1): 85-8.
  7. Poelman MC, Piot B, Guyon F, Deroni M, Leveque JL. Assessment of topical non-steroidal anti-inflammatory drugs. J Pharm Pharmacol 1989; 41(10): 720-2.
  8. Moore RA, Tramer MR, Carroll D, Wiffen PJ, McQuay HJ. Quantitative systematic review of topically applied non-steroidal anti-inflammatory drugs. BMJ 1998; 316(7128): 333-8.
  9. van Haselen RA, Fisher PA. A randomized controlled trial comparing topical piroxicam gel with a homeopathic gel in osteoarthritis of the knee. Rheumatology (Oxford) 2000; 39(7): 714-9.
  10. O'Hanlon JJ, McCleane G, Muldoon T. Preoperative application of piroxicam gel compared to a local anaesthetic field block for postoperative analgesia. Acta Anaesthesiol Scand 1996; 40(6): 715-8.
  11. Akinturk S, Eroglu A. Effect of piroxicam gel for pain control and inflammation in Nd:YAG 1064-nm laser hair removal. J Eur Acad Dermatol Venereol 2007; 21(3): 380-3.
  12. Dutta A, Puri GD, Wig J. Piroxicam gel, compared to EMLA cream is associated with less pain after venous cannulation in volunteers. Can J Anaesth 2003; 50(8): 775-8.
  13. Ahmadinejad M, Delfan B, Haghdani S, Hashemi M, Khan IA, Tafti MT. Comparing the effect of diclofenac gel and piroxicam gel on mastalgia. Breast J 2010; 16(2): 213-4.
Journal of Isfahan Medical School
Volume 29, Issue 140 - Serial Number 140
March and April 2011
Pages 644-650

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History

  • Receive Date: 18 June 2011
  • Revise Date: 04 May 2024
  • Accept Date: 06 April 2022

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