Evaluatiin the Effectiveness of Magnesium Sulfate Nebulizer in

Document Type : Original Article (s)

Authors

1 Assistant Professor, Department of Pediatrics, Child Health Promotion Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan. Iran

2 Associate Professor, Department of Pediatrics, Child Health Promotion Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan.Iran

3 Resident, Department of Pediatrics, Child Health Promotion Research Center, School of Medicine And Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

4 Pediatrician, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Acute Bronchiolitis is a common seasonal lower respiratory disease in infants. Syncytial respiratory virus is responsible for more than 50 percent of bronchiolitis events. The treatment is usually supportive. This study was done to examine the efficacy of nebulizer magnesium sulfate in the treatment of acute bronchiolitis.Methods: This study was a double blind clinical trial in which 60 patients admitted with acute bronchiolitis in Alzahra, Amin and Shariati hospitals in Isfahan, Iran during 2010 and 2011 were studied. Patients were randomly divided into two groups, A and B. Group A were treated by magnesium sulfate, epinephrine and normal saline and group B were treated only by epinephrine and normal saline. Severity of symptoms was investigated by measuring the temperature, SPO2, pulse rate (PR), respiratory rate (RR) and respiratory distress assessment instrument (RDAI) index, at the beginning of stuy to 3 days after treatment by follow-up questionnaires. Data were analyzed by Student t-test and repeated measure ANOVA.Findings: The mean of temperature, SPO2, PR, RR and RDAI at admission and during hospital stay was not significantly different between two groups. After removing the confounding effect of different arrival, RDAI in second and third days in group A was significantly less than group B (P < 0.01). Conclusion: According to this study, treatment with magnesium sulfate has no effect on symptoms of acute bronchiolitis. Magnesium sulfate can reduce RDAI only in the second and third days of hospitalization.

Keywords

References

  1. Goodman D. Inflammatory Disorder of the Small. In: Behrman RE, Kliegman RM, Jenson HB, Editors. Nelson Textbook of Pediatrics. 17th ed. Philadelphia: WB. Saunders; 2003. p. 1415-7.
  2. Wright AL, Taussig LM, Ray CG, Harrison HR, Holberg CJ. The Tucson Children's Respiratory Study. II. Lower respiratory tract illness in the first year of life. Am J Epidemiol 1989; 129(6): 1232-46.
  3. Kellner JD, Ohlsson A, Gadomski AM, Wang EE. Bronchodilators for bronchiolitis. Cochrane Database Syst Rev 2000; (2): CD001266.
  4. Ralston S, Hartenberger C, Anaya T, Qualls C, Kelly HW. Randomized, placebo-controlled trial of albuterol and epinephrine at equipotent beta-2 agonist doses in acute bronchiolitis. Pediatr Pulmonol 2005; 40(4): 292-9.
  5. Beck R, Elias N, Shoval S, Tov N, Talmon G, Godfrey S, et al. Computerized acoustic assessment of treatment efficacy of nebulized epinephrine and albuterol in RSV bronchiolitis. BMC Pediatr 2007; 7: 22.
  6. Langley JM, Smith MB, LeBlanc JC, Joudrey H, Ojah CR, Pianosi P. Racemic epinephrine compared to salbutamol in hospitalized young children with bronchiolitis; a randomized controlled clinical trial [ISRCTN46561076]. BMC Pediatr 2005; 5(1): 7.
  7. Scarfone RJ, Loiselle JM, Joffe MD, Mull CC, Stiller S, Thompson K, et al. A randomized trial of magnesium in the emergency department treatment of children with asthma. Ann Emerg Med 2000; 36(6): 572-8.
  8. Bertrand P, Aranibar H, Castro E, Sanchez I. Efficacy of nebulized epinephrine versus salbutamol in hospitalized infants with bronchiolitis. Pediatr Pulmonol 2001; 31(4): 284-8.
  9. Lowell DI, Lister G, Von Koss H, McCarthy P. Wheezing in infants: the response to epinephrine. Pediatrics 1987; 79(6): 939-45.
  10. Kimpen JL. Prevention and treatment of respiratory syncytial virus bronchiolitis and postbronchiolitic wheezing. Respir Res 2002; 3(Suppl 1): S40-S45.
  11. Ciarallo L, Brousseau D, Reinert S. Higher-dose intravenous magnesium therapy for children with moderate to severe acute asthma. Arch Pediatr Adolesc Med 2000; 154(10): 979-83.
  12. Gourgoulianis KI, Chatziparasidis G, Chatziefthimiou A, Molyvdas PA. Magnesium as a relaxing factor of airway smooth muscles. J Aerosol Med 2001; 14(3): 301-7.
  13. Mull CC, Scarfone RJ, Ferri LR, Carlin T, Salvaggio C, Bechtel KA, et al. A randomized trial of nebulized epinephrine vs albuterol in the emergency department treatment of bronchiolitis. Arch Pediatr Adolesc Med 2004; 158(2): 113-8.
  14. Ray MS, Singh V. Comparison of nebulized adrenaline versus salbutamol in wheeze associated respiratory tract infection in infants. Indian Pediatr 2002; 39(1): 12-22.
  15. Menon K, Sutcliffe T, Klassen TP. A randomized trial comparing the efficacy of epinephrine with salbutamol in the treatment of acute bronchiolitis. J Pediatr 1995; 126(6): 1004-7.
  16. Abul-Ainine A, Luyt D. Short term effects of adrenaline in bronchiolitis: a randomised controlled trial. Arch Dis Child 2002; 86(4): 276-9.
Journal of Isfahan Medical School
Volume 29, Issue 152 - Serial Number 152
July and August 2011
Pages 1229-1234

Files

History

  • Receive Date: 18 June 2011
  • Revise Date: 02 May 2024
  • Accept Date: 06 April 2022

Share

How to cite

Statistics