Seroprevalence of Human Cytomegalovirus Diseases in Isfahan, Iran

Document Type : Original Article (s)

Authors

1 Associate Professor, Infectious Diseases and Tropical Medicine Research Center, Child Health Promotion Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Student of Medicine, Infectious Diseases and Tropical Medicine Research Center, Child Health Promotion Research Center And Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

3 Research Assistant, Infectious Diseases and Tropical Medicine Research Center, Child Health Promotion Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

4 Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

5 Community and Preventive Medicine Specialist, Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Human cytomegalovirus (HCMV) is one of the commonest agents that cause congenital malformation such as mental retardation and deafness. Seroprevalence of HCMV varies in different populations and age groups. This study tried to determine the seroprevalence and contributory factors of CMV in order to develop successful strategies for HCMV diseases prevention.Methods: We examined 595 serum samples from different age groups for the presence of IgG antibodies against HCMV by enzyme-linked immunosorbent assay (ELISA) technique.Findings: Overall, 586 out of 595 cases were seropositive for HCMV-IgG while 9 cases were seronegative. Educational level, sex, marital status, and place of residence were not associated with CMV seropositivity. Conclusion: Our results indicated that in Isfahan, Similar to other developing countries, most patients are infected during puberty and not through sexual intercourse. Therefore, frequent audiological assessments and urine samples to evaluate CMV in case of defect in hearing ability are mandatory. We also recommend transmission of eradicated blood for immunocompromised patient and immature neonates.

Keywords

References

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Journal of Isfahan Medical School
Volume 29, Issue 168 - Serial Number 168
November and December 2012
Pages 2475-2483

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History

  • Receive Date: 08 September 2011
  • Revise Date: 30 April 2024
  • Accept Date: 06 April 2022

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