Modeling of the Effects of Turbulence Intensity on Mechanical Hemolysis of Red Blood Cells

Document Type : Original Article(s)

Authors

1 Assistant Professor, Department of Heat and Fluid, School of Mechanical and Aerospace Engineering, Shiraz University of Technology, Shiraz, Iran

2 Associate Professor, Department of Mechanical Engineering, School of Engineering, Tarbiat Modares University, Tehran, Iran

3 Department of Microbiology, School of Biological Sciences, Shahid Beheshti University, Tehran, Iran

Abstract

Background: Mechanical hemolysis plays an important role in development of cardiovascular prostheses, artificial valves, and blood pumps. Considerable research has been conducted to investigate mechanical hemolysis of red blood cells (RBC). Most previous studies have focused on the effects of Reynolds number of blood flow and mean value of turbulent stresses. However, less attention has been paid to the influence of eddy length scale and turbulence intensity.Methods: In this study, a new analytical correlation was proposed in order to predict the mechanical hemolysis due to turbulence effects. The roles of Reynolds number and relative turbulence intensity were clearly demonstrated in the proposed correlation. The good agreement between predicted results and the experimental data showed that the proposed model had good accuracy.Findings: RBCs can tolerate up to 20% of turbulence intensity depending on the value of Reynolds number of the blood flow. In addition, the maximum endurable value of turbulence intensity of a human RBC decreases as Reynolds number of the blood flow increases.Conclusion: For the first time, this paper showed that mechanical hemolysis of RBC can be intensely influenced by the turbulence intensity of blood flow. Therefore, a simple explicit analytical criterion was proposed for prediction of the effects of turbulence intensity on mechanical hemolysis of RBC.

Keywords

References

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Journal of Isfahan Medical School
Volume 29, Issue 174 - Serial Number 174
November and December 2011
Pages 3251-3257

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History

  • Receive Date: 05 May 2012
  • Revise Date: 26 April 2024
  • Accept Date: 06 April 2022

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