Journal of Isfahan Medical School

Journal of Isfahan Medical School

Evaluating the Sensitivity of Nontuberculous Mycobacterial Species Isolated from Water Samples to Conventional Antimycobacterial Drugs using E-Test Method

Document Type : Original Article(s)

Authors
Ensieh Sarikhani 1
Bahram Nasr Isfahani 2
Nafiseh Sadat Hosseini 3
Tahmineh Narimani 3
1 MSc Student, Student Research Committee, Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Assistant Professor, Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Background: Nontuberculous mycobacteria were only known as environmental bacteria. However, they have recently been identified as important pathogens due to the increased prevalence of immunodeficiency diseases. Mycobacterial susceptibility testing is thus vital in management of patients with mycobacterial infections. Methods: In this study, different samples were collected from different water sources in Isfahan, Iran. The samples were then cultured to detect environmental mycobacteria. After confirming the species, E-test was used to determine the sensitivity of 14 nontuberculous mycobacterial isolates. Findings: Minimal inhibitory concentrations of 8 current routine antibiotics against mycobacterial infections were examined. Conclusion: This study showed different nontuberculous mycobacteria to be highly resistant to rifampin and isoniazid. Resistance to other drugs was species-dependent. Keywords: Nontuberculous mycobacteria, Antibiotic resistance, E-test

  • Receive Date 23 August 2011
  • Accept Date 06 April 2022