Journal of Isfahan Medical School

Journal of Isfahan Medical School

A Comparison between the Effects of Glucantime, Topical Trichloroacetic Acid 50% plus Glucantime, and Fractional Laser plus Glucantime on Cutaneous Leishmaniasis Lesions

Document Type : Original Article (s)

Authors
Mohammad Ali Nilforoushzadeh 1
Amir Hosein Siadat 2
Nazli Ansari 3
Elaheh Haftbaradaran 3
Elham Ahmadi 3
1 Associate Professor, Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran AND Skin Disease and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Assistant Professor, Skin Disease and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
3 General practitioner, Skin Disease and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Background: Cutaneous leishmaniasis is an endemic disease in Iran. Pentavalent antimonial drugs have been the first line of therapy in cutaneous leishmaniasis for many years. However, the cure rate of these agents is still not favorable. This study was carried out to compare the effects of topical trichloroacetic acid 50% in combination with glucantime, intralesional glucantime plus fractional laser, and glucantime alone on cutaneous leishmaniasis. Methods: A total of 90 patients were randomly divided into three groups of 30 to be treated with intralesional injection of meglumine antimoniate (glucantime), a combination of topical trichloroacetic acid 50% and glucantime, or a combination of fractional laser and glucantime. Complete cure rate and changes in sizes of lesions and scars were assessed and compared between groups. Findings: The mean duration of treatment was 6.1 ± 2.1 weeks in all patients (range: 2-12 weeks) and 6.8 ± 1.7, 5.2 ± 1.0, and 6.3 ± 3.0 weeks in glucantime, topical trichloroacetic acid plus glucantime, and fractional laser plus glucantime groups, respectively (P = 0.011). The mean score of scars was 3.7 ± 0.6, 3.6 ± 0.8, and 6.3 ± 0.7 in the above-mentioned groups (P < 0.001). Conclusion: Compared to glucantime alone, the combination of intralesional glucantime and trichloroacetic acid 50% or fractional laser had significantly higher and faster cure rate in patients with cutaneous leishmaniasis. Keywords: Meglumine antimoniate, Glucantime, Trichloroacetic acid, Fractional laser, Cutaneous leishmaniasis
Journal of Isfahan Medical School
Volume 30, Issue 221 - Serial Number 221
November and December 2013
Pages 2450-2459

  • Receive Date 25 December 2012
  • Accept Date 06 April 2022