Journal of Isfahan Medical School

Journal of Isfahan Medical School

Correlation of C-Reactive Protein (CRP) in Blood and the Atherosclerotic Plaque and its Severity in Patients with Diabetes Mellitus Undergoing Coronary Artery Bypass Graft Surgery

Document Type : Original Article (s)

Authors
Shaghayegh Haghjooy Javanmard 1
Mohsen Mirmohammad-Sadeghi 2
Seyed Mohammad Hashemi-Jazi 3
Hooria Seyedhosseini Ghaheh 4
Azam Mosayebi 5
1 Associate Professor, Department of Physiology, School of Medicine AND Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Assistant Professor, Department of Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Professor, Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4 Young Researchers and Elites club, Science and Research Branch, Islamic Azad University, Tehran, Iran
5 Department of Nursing, Kashani Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Background: Atherosclerosis is a chronic inflammatory disease. There are several inflammatory molecules involved in the development of atherosclerosis. Among them, C-reactive Protein (CRP) is the best known biomarker for disease progression, plaque instability and fragility. This study aimed to determine the correlation of the venous CRP with plaque CRP in patients undergoing elective coronary artery bypass graft (CABG) surgery.Methods: This study was done on 22 men with diabetes mellitus candidate for CABG surgery. Blood samples were taken from patients before surgery to determine the venous blood CRP level. The atherosclerotic plaque was removed from the vessel wall during the surgery. Samples of coronary atherosclerotic plaques were stained with Hematoxilin and Eosin to measure intima and media thickness and calculate the intima to media ratio (IMR). The immunohistochemistry staining was used to determine the CRP expression levels. Venous blood hsCRP concentrations were determined by ELISA method.Findings: There was no significant correlation between the intensity of CRP expression in atherosclerosis plaques and hsCRP concentrations in venous blood; but there was a significant correlation between the venous blood hsCRP concentration and severity of atherosclerosis (the IMR).Conclusion: Increased CRP represents systemic inflammation in the body and is correlated with the severity of atherosclerosis; so, it can be a reliable biomarker of disease progression. Despite of the existence of CRP in the atherosclerotic plaque, there is no correlation between the expression of CRP and hsCRP concentrations.
Keywords
Coronary atherosclerosis
C-Reactive Protein
Coronary Artery Bypass Graft Surgery
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Journal of Isfahan Medical School
Volume 31, Issue 228 - Serial Number 228
January and February 2013
Pages 247-254

  • Receive Date 09 November 2012
  • Accept Date 06 April 2022