Journal of Isfahan Medical School

Journal of Isfahan Medical School

Comparative Study of the Effects of Two Anesthetic Methods with Propofol and Isoflurane on Mother’s Awareness during the Operation and APGAR Score in the Newborns Delivered by Elective Cesarean Section

Document Type : Original Article (s)

Authors
Mahdieh Mehmandoost 1
Khosrou Naghibi 2
1 Student of Medicine, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
2 Associate Professor, Department of Anesthesiology and Critical Care, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Background: In Iran, general anaesthesia is more common than other anaesthetic methods in caesarean section and it is the first choice for pregnant mothers. So, we designed this study to compare the effect of isoflurane and propofol on mother’s awareness and APGAR score in the neonatal delivered by selective caesarean section.Methods: In this double blind clinical trial study, 90 pregnant women (18-35-years old) with American Society of Anesthesiologists (ASA) classification 1 or 2, who were condidate for selective caesarean, randomly assigned to two groups. Induction of anaesthesia was provided by propofol and succinylcholine in the same way, and maintenance of anaesthesia was provided by propofol in group 1 (100 µg/kg/min) and with isoflurane 1 MAC (Minimum alveolar concentration) in group 2 to maintain Bispectral index score (BIS) between 45 and 60. For statistical analysis t and chi-square tests were used.Findings: There was not a significant difference between the two groups in basic information, neonatal APGAR scores, and hemodynamic changes. 7 of 90 patients had dreams after being awakened (8.9 vs 6.7 percent in propofol and isoflurane groups, respectively) but no significant difference was detected.Conclusion: There was not a significant difference between two groups in هncidence of awareness, neonatal APGAR scores, and hemodynamic changes which correlated with other studies. Although, more studies with larger sample size needed to compare the effect of these two drugs.
Keywords
Cesarean section
Bispectoral index
APGAR score
Awareness
Propofol
Isoflurane
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Journal of Isfahan Medical School
Volume 31, Issue 228 - Serial Number 228
January and February 2013
Pages 265-273

  • Receive Date 06 April 2013
  • Accept Date 06 April 2022