The Quality of Life in Children with Nephritic Syndrome in Isfahan, Iran

Document Type : Original Article (s)

Authors

1 Associate Professor, Department of Pediatrics, School of Medicine AND Isfahan Kidney Diseases Research Center AND Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Associate Professor, Department of Community and Preventive Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Student of Medicine, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

4 Assistant Professor, Department of Pediatrics, School of Medicine AND Isfahan Kidney Diseases Research Center AND Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: The children with nephrotic syndrome suffer from various complications such as nutritional deprivations, frequent hospitalization and drug side-effects. In this study, we aimed to evaluate the quality of life in children with nephrotic syndrome who have not been progressing to end-stage renal disease (ESRD) yet.Methods: In this cross-sectional study, after receiving written consent from both child and his/her parents, children who have nephrotic syndrome, with age of less than 18 years and glomerular filtration rate (GFR) of more than 90 ml/min, were entered. PedsQL Tm 4.0 generic core scale was used for data recording. Demographic and laboratory data, as well as drugs history and period of disease and being responsive or irresponsive to steroids, were recorded and analyzed either. Findings: 25.3% were between 2 to 4 years, 42.7% between 5 to 7 years, 21.3% between 8 to 12 years, and 10.6% were between 13 to 18 years. There was significant statistical difference among groups regarding physical, emotional, social and school performance. The differences between groups were analyzed and the most significant difference was among the children of 5 to 7 years old when considering quality of life in social and school performance. But, we did not find any co-relation between the measured quality of life and paraclinical data.Conclusion: In this study, we concluded that children with nephrotic syndrome need more attention regarding social activities to help them in improving their quality of life.

Keywords

References

  1. Chang JW, Tsai HL, Yang LY, Chen TJ. Epidemiology and predictors of end-stage renal disease in Taiwanese children with idiopathic nephrotic syndrome. J Epidemiol 2012; 22(6): 517-22.
  2. Gipson DS, Massengill SF, Yao L, Nagaraj S, Smoyer WE, Mahan JD, et al. Management of childhood onset nephrotic syndrome. Pediatrics 2009; 124(2): 747-57.
  3. Goldstein SL, Graham N, Burwinkle T, Warady B, Farrah R, Varni JW. Health-related quality of life in pediatric patients with ESRD. Pediatr Nephrol 2006; 21(6): 846-50.
  4. McKenna AM, Keating LE, Vigneux A, Stevens S, Williams A, Geary DF. Quality of life in children with chronic kidney disease-patient and caregiver assessments. Nephrol Dial Transplant 2006; 21(7): 1899-905.
  5. Gipson DS, Selewski DT, Massengill SF, Wickman L, Messer KL, Herreshoff E, et al. Gaining the PROMIS perspective from children with nephrotic syndrome: a Midwest pediatric nephrology consortium study. Health Qual Life Outcomes 2013; 11: 30.
  6. Al Salloum AA, Muthanna A, Bassrawi R, Al Shehab AA, Al IA, Islam MZ, et al. Long-term outcome of the difficult nephrotic syndrome in children. Saudi J Kidney Dis Transpl 2012; 23(5): 965-72.
  7. Gheissari A, Farajzadegan Z, Heidary M, Salehi F, Masaeli A, Mazrooei A, et al. Validation of Persian Version of PedsQL 4.0 Generic Core Scales in Toddlers and Children. Int J Prev Med 2012; 3(5): 341-50.
  8. Roccella M, Leggio L, Parisi L, Turdo G, Testa D. The quality of life in developing age subjects with chronic renal diseases. Minerva Pediatr 2005; 57(3): 119-28. [In Italian].
  9. Neuhaus TJ, Langlois V, Licht C. Behavioural abnormalities in children with nephrotic syndrome--an underappreciated complication of a standard treatment? Nephrol Dial Transplant 2010; 25(8): 2397-9.
  10. Fietta P, Fietta P, Delsante G. Central nervous system effects of natural and synthetic glucocorticoids. Psychiatry Clin Neurosci 2009; 63(5): 613-22.
  11. Ramos-Remus C, Gonzalez-Castaneda RE, Gonzalez-Perez O, Luquin S, Garcia-Estrada J. Prednisone induces cognitive dysfunction, neuronal degeneration, and reactive gliosis in rats. J Investig Med 2002; 50(6): 458-64.
  12. Guha P, De A, Ghosal M. Behavior profile of children with nephrotic syndrome. Indian J Psychiatry 2009; 51(2): 122-6.
  13. Shutto Y, Yamabe H, Shimada M, Fujita T, Nakamura N. Quality of life in patients with minimal change nephrotic syndrome. Scientific World Journal 2013; 2013: 124315.
  14. Ruth EM, Landolt MA, Neuhaus TJ, Kemper MJ. Health-related quality of life and psychosocial adjustment in steroid-sensitive nephrotic syndrome. J Pediatr 2004; 145(6): 778-83.
  15. Park KS, Cho MH, Ha IS, Kang HG, Cheong HI, Park YS, et al. Validity and reliability of the Korean version of the pediatric quality of life ESRD module. Health Qual Life Outcomes 2012; 10: 59.
Journal of Isfahan Medical School
Volume 31, Issue 229 - Serial Number 229
January and February 2013
Pages 323-331

Files

History

  • Receive Date: 28 April 2013
  • Revise Date: 29 April 2024
  • Accept Date: 06 April 2022

Share

How to cite

Statistics