Journal of Isfahan Medical School

Journal of Isfahan Medical School

The Effect and Mechanism of Action of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 in Human Breast Cancer; A Systematic Review

Document Type : Review Article

Authors
Emad Khodadadi 1
Negar Ataei 2
Mohammad-Reza Mofid 3
1 MSC Student, Department of Medical Biochemistry, School of Pharmacy and Pharmaceutical Sciences AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
2 PhD Student, Department of Medical Biochemistry, School of Pharmacy and Pharmaceutical Sciences AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
3 Assistant Professor, Department of Medical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Background: Breast cancer is the most common malignancy in women. Many factors such as estrogens, nutrition, etc. play role in the incidence of this cancer. Insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) are the factors recently considered as  components of insulin-like growth factor (IGF) system.Methods: Studies in this field from 1987 to 2012 by using the databases of NCBI (http://www.ncbi.nlm.nih.gov/) were analyzed and reviewedFindings: 1181 article had examined the effect of IGF-1 in breast cancer. 46 showed a direct association with breast cancer. 92 articles were studied relation of IGF-1 and IGFBP-3 with breast cancer, 9 of them were review articles. Of these, 30 articles were selected as the main references.Conclusion: Studies have shown that IGF-1 gene expression increases in breast cancer. IGF-1 effects in growth, proliferation and tumor genesis is mediated by IGF-1R. IGFBP3 inhibit IGF-1 effects by preventing its binding to a surface receptor (IGF-1R) and interferes with IGF-1 mitoses action. Also, in a mechanism independent on IGF, IGFBP-3 binds to specific membrane proteins and induces apoptosis and inhibits cell growth.
Keywords
Breast Cancer
IGFBP3
IGF-1
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Journal of Isfahan Medical School
Volume 31, Issue 254 - Serial Number 254
July and August 2013
Pages 1560-1567

  • Receive Date 09 May 2013
  • Accept Date 06 April 2022