Journal of Isfahan Medical School

Journal of Isfahan Medical School

Impact of Preoperative Clopidogrel Administration on Perioperative Blood Loss and Transfusion Requirements in Patients Undergoing Coronary Artery Bypass Graft Surgery

Document Type : Original Article (s)

Authors
Keyvan Bagheri 1
Seyed Mohammad Reza Safavi 2
Azim Honarmand 2
Mohammadali Attari 2
Masoud Nazem 3
Javad Ahmadi 4
Mehdi Khazaei 4
1 Assistant Professor, Department of Anesthesiology and Critical Care, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Associate Professor, Department of Anesthesiology and Critical Care, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Associate Professor, Department of Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4 Student of Medicine, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Background: Clopidogrel is an adenosine-5' diphosphate (ADP) receptor antagonist that eventually inhibits platelet aggregation. It is used concomitantly with percutaneous coronary interventions and in patients with acute coronary diseases. This study was conducted to determine the effects of preoperative clopidogrel administration on perioperative blood loss and transfusion requirements in patients undergoing coronary artery bypass graft (CABG) surgery.Methods: For 100 patients who underwent nonurgent first-time coronary artery bypass grafting surgery participated in this study. clopidogrel was discontinued in 2, 3, 5-6 or 7-8 days before surgery. A cell salvage device was used during surgery and salvaged blood was recorded. After surgery, chest tube output and need for blood transfusion were measured and recorded.Findings: Patients' mean age was 61.7 ± 8.0 years (range: 50 to 77). There was a reverse relation between the time clopidogrel had been discontinued and blood loss and need for transfusion of packed cell and blood products during and after surgery (P < 0.05 for all).Conclusion: Preoperative clopidogrel administration increases perioperative blood loss and need for blood transfusion in patients undergoing coronary artery bypass grafting surgery.
Keywords
Clopidogrel
Coronary artery bypass grafting (CABG) surgery
Blood loss
Transfusion
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Journal of Isfahan Medical School
Volume 31, Issue 270 - Serial Number 270
November and December 2014
Pages 2382-2389

  • Receive Date 21 September 2013
  • Accept Date 06 April 2022