Investigating the Effect of Zinc Chloride on Control of Liver Hemorrhage; an Animal Model Study

Document Type : Original Article (s)

Authors

1 General Practitioner, Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

2 Associate Professor, Trauma Research Center, Kashan University of Medical Sciences, Kashan, Iran

Abstract

Background: The control of parenchymal hemorrhage, especially in liver parenchyma, despite surgical science progresses, is still one of the challenges surgeons face saving the patients’ lives; and there is a research challenge between the researchers in this field to introduce a more effective method. This study aimed to determine the hemostatic effect of zinc chloride on controlling the bleeding from liver parenchymal tissue.Methods: In this animal model study, 60 male Wistar rats were used. An incision with length of 2 and depth of 0.5 cm was made on each mouse’s liver and the hemostasis time was measured using zinc chloride different concentrations (5%, 10%, 15%, 25%, and 50%) and the control method (i.e. control of bleeding via suturing).Findings: In all the groups, complete hemostasis occurred; the hemostasis times of zinc chloride concentration groups were significantly less than that of the control group (P < 0.001). At concentrations of 5%, 10% and 15% of zinc chloride and suture group, pathological grade one was seen. In addition, in the 25% and 50% zinc chloride groups, pathological grade two was the most common grade (70% and 80%, respectively).Conclusion: Zinc chloride is an effective hemostatic agent in controlling liver parenchymal tissue hemorrhage in an animal model; it can control the liver bleeding, also at the lowest concentration (5%).

Keywords

References

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Journal of Isfahan Medical School
Volume 32, Issue 308 - Serial Number 308
September and October 2015
Pages 1845-1854

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History

  • Receive Date: 26 April 2014
  • Revise Date: 03 May 2024
  • Accept Date: 06 April 2022

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