Journal of Isfahan Medical School

Journal of Isfahan Medical School

The Effect of Melanocyte Cell Suspension in Jokliks Medium in the Treatment of Stable Resistant Vitiligo: Report of 10 Cases

Document Type : Case Report

Authors
Mohammad Ali Nilforoushzadeh 1
Fariba Jaffary 2
Elaheh Haftbaradaran 3
Mohammad Hossein Nasr-Esfahani 4
1 Associate Professor, Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
2 Associate Professor, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan AND Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
3 General Practitioner, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
4 Embryologist, Rooyan Institute, Isfahan, Iran
Abstract
Background: Vitiligo is a cosmetically disfiguring acquired depigmenting disorder caused by the loss of functional melanocytes in the epidermis. Various approaches used for the treatment of vitiligo can be classified as medical and surgical therapies. Non-cultured autologous melanocyte transplantation is a new and effective surgical treatment for stable vitiligo. This study aimed to evaluate the effect of the melanocyte cell suspension in Jokliks medium in the treatment of stable resistant vitiligo.Methods: Ten patients with stable vitiligo, resistant to standard treatment, underwent the treatment via melanocyte cell suspension in Jokliks medium. The repigmentation was assessed during 3 weeks, and 3 and 6 months. Findings: The mean repigmentation of 10 patients with 16 lesions was 14% in 3 weeks, 37% in 3 month and 42% in 6 month that was poor repigmentation (less than 50%).Conclusion: Results of this pilot study showed less than 50% repigmentation using melanocyte cell suspension in Jokliks medium, especially in light skin type patients, without using adjunct treatments like phototherapy. 
Keywords
Vitiligo
Melanocyte cell suspension
Resistant
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Journal of Isfahan Medical School
Volume 32, Issue 314 - Serial Number 314
November and December 2015
Pages 2210-2216

  • Receive Date 16 December 2014
  • Accept Date 06 April 2022