Journal of Isfahan Medical School

Journal of Isfahan Medical School

Treatment of Recalcitrant Diabetic Ulcers with Trichloroacetic Acid and Fibroblasts; Case Report

Document Type : Case Report

Authors
Mohammad Ali Nilforoushzadeh 1
Fariba Jaffary 2
Mansour Siavash 3
Asieh Heidari 4
Nazli Ansari 5
Amir Hossein Siadat 6
1 Associate Professor, Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
2 Associate Professor, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan AND Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
3 Associate Professor, Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
4 Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
5 General Practitioner, Researcher, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
6 Assistant Professor, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Background: Foot ulcer, with a prevalence of 15% in general population, is one of the main complications in patients with diabetes. So far, different therapeutic methods have been provided for the treatment of foot ulcers. When no response to the standard treatment methods is observed, other methods would be applied.Case Report: In this report, we introduce two men with type 2 diabetes mellitus and recalcitrant diabetic foot ulcer who were treated with topical 50% trichloroacetic acid solvent and autologous fibroblasts. The treatment resulted in complete healing of foot ulcers in both patients.Conclusion: Trichloroacetic acid and autologous fibroblast can be considered as therapeutic choice for recalcitrant diabetic foot ulcer. 
Keywords
Trichloroacetic acid
Autologous fibroblasts
Recalcitrant diabetic ulcer
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Journal of Isfahan Medical School
Volume 32, Issue 315 - Serial Number 315
November and December 2015
Pages 2252-2259

  • Receive Date 25 December 2014
  • Accept Date 06 April 2022