Efficacy of Adding Baclofen to Treat Patients with Non-Erosive Reflux Disease Resistant to Treatment

Document Type : Original Article (s)

Authors

1 Student of Medicine, Department of Medicine, Islamic Azad University, Najafabad Branch, Isfahan, Iran

2 Assistant Professor, Department of Internal Medicine, Islamic Azad University, Najafabad Branch, Isfahan, Iran

3 Assistant Professor, Department of Medicine, Islamic Azad University, Najafabad Branch, Isfahan, Iran

Abstract

Background: Non-erosive reflux disease (NERD) is one of the categories of gastro-esophageal reflux disease defined as the presence of classic reflux symptoms in the absence of esophageal mucosal injury during upper endoscopy. The efficacy of proton pump inhibitor (PPI) is observed in these patients and it is demonstrated that the proportion of them respond to a standard dose of proton pump inhibitors lower than patients with erosive esophagitis. Baclofen, a gamma-aminobutyric acid-B (GABAB) agonist, has been shown to reduce transient lower esophageal sphincter relaxations (TLESRs), a major cause of gastro-esophageal reflux disease. This study aimed to investigate the efficacy of adding baclofen to treat patients with non-erosive reflux disease resistant to proton-pump-inhibitor treatment.Methods: Ninety patients with non-erosive reflux disease resistant to treatment with proton pump inhibitor were randomly divided into two groups. The first group received baclofen (20 mg per day) plus omeprazole (20 mg per day) and the second group received only omeprazole (20 mg per day). After 2 months, the findings were compared.Findings: Differences in age, sex, weight, previous treatment with proton pump inhibitor, existence of hiatal hernia and previous treatment of Helicobacter pylori were not significant between the groups. Patients receiving baclofen plus omeprazole had significantly less heart burn (P = 0.014), regurgitation (P = 0.012), sour taste (P = 0.029) and belching (P = 0.001).Conclusion: The data suggest that baclofen plus omeprazole have additive effects in treatment of patients with non-erosive reflux disease.

Keywords

References

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Journal of Isfahan Medical School
Volume 33, Issue 323 - Serial Number 323
January and February 2015
Pages 144-151

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History

  • Receive Date: 23 February 2015
  • Revise Date: 02 May 2024
  • Accept Date: 06 April 2022

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