Journal of Isfahan Medical School

Journal of Isfahan Medical School

Interobserver Variation in Grading and Staging of Chronic Hepatitis Using Knodell Ishak (Modified HAI) or Batts-Ludwig Scoring Systems

Document Type : Original Article (s)

Authors
Mitra Heidarpour 1
Mohammad Hosein Sanei 1
Parvin Rajabi 2
Azin Momeni 3
1 Associate Professor, Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Professor, Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Student of Medicine, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Background: Reliable assessment of liver histopathology in patients with chronic hepatitis is important for assessing the severity of the disease. This study aimed to survey the interobserver variability of liver biopsy assessment performed via two of the most commonly used systems.Methods: 54 liver biopsies from patients with chronic hepatitis were scored by three independent observers using Knodell Ishak [modified histology activity index (HAI)] and Batts-Ludwig systems.Findings: The best agreement was seen for Knodell Ishak’s staging (Kendall’s correlation coefficient (r) = 90%, P < 0.001). The worst agreement was seen for Batts-Ludwig grading. (r = 63%, P < 0.001).Conclusion: We conclude that both systems showed better agreement for staging than for grading; while both systems produced reasonable agreement between the observers, Knodell Ishak system showed greater results.
Keywords
Liver biopsy
Grading
Staging
Chronic hepatitis
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Journal of Isfahan Medical School
Volume 33, Issue 344 - Serial Number 344
May and June 2015
Pages 1211-1219

  • Receive Date 28 May 2014
  • Accept Date 06 April 2022