Journal of Isfahan Medical School

Journal of Isfahan Medical School

Comparing the Preventive Effect of Combination of Ketamine with Metoclopramide or Fentanyl on the Postoperative Pain after Laparoscopic Cholecystectomy under General Anesthesia

Document Type : Original Article (s)

Authors
Seyed Mortaza Heidari-Tabaee-Zavare 1
Mehran Qanavi 2
Leila Raeesi 3
1 Professor, Department of Anesthesiology and Critical Care, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Student of Medicine, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
3 Nurse Anesthetist, Operating Room, Alzahra Hospital, Isfahan, Iran
Abstract
Background: Pain is one of the most common postoperative complications that can be reduced via different methods like combination of two or more drugs to make synergistic effect. This research aimed to comparing the preventive effect of using combination of ketamine and fentanyl or ketamine and metoclopramide on the postoperative pain after laparoscopic cholecystectomy.Methods: In a double-blinded clinical trial study, 90 patients in class I and II of ASA (American Society of Anesthesiologists) classification who were candidates for laparoscopic cholecystectomy were divided into two groups. Half an hour before completion of the operation, patients in the first group received intravenous metoclopramide (0.1 mg/kg) and ketamine (0.5 mg/kg) slowly; while the patients in the second group received intravenous ketamine (0.5 mg/kg) and fentanyl (0.5 µg/kg) slowly. After completion of operation, the pain severity was evaluated based on the visual analogue score (VAS) and the data were compared between the two groups.Findings: The main pain score in ketamine and metoclopramide group at the end of recovery, also at the 2nd, 6th, 12th, 24th postoperative hours, was significantly lower than ketamine and fentanyl group (P < 0.001).Conclusion: Preventive administration of ketamine and metoclopramide causes more reduction in postoperative pain than ketamine and fentanyl and is not associated with any severe postoperative complication.
Keywords
Postoperative pain
Metoclopramide
Ketamine
Fentanyl
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Journal of Isfahan Medical School
Volume 33, Issue 347 - Serial Number 347
July and August 2015
Pages 1357-1369

  • Receive Date 19 May 2015
  • Accept Date 06 April 2022