Journal of Isfahan Medical School

Journal of Isfahan Medical School

Is There Any Difference in the Levels of Antibodies against Helicobacter Pylori Infection between the Patients with Migraine Headache with or without Aura?

Document Type : Original Article (s)

Authors
Behnaz Ansari 1
Rokhsareh Meamar 2
Ahmad Chitsaz 3
1 Assistant Professor, Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Assistant Professor, Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences AND Department of Pharmacology, School of Medical Sciences, Najafabad Branch, Islamic Azad University, Isfahan, Iran
3 Professor, Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Background: Recent studies have focused on a positive correlation between Helicobacter pylori (H. pylori) infection and occurrence of migraine headache. This study aimed to determine the role of H. pylori infection in the two common types of migraine headache including with (MA) and without aura (MO).Methods: In a case-control study, 84 patients (with MA or MO migraine headache) and 49 healthy individuals were enrolled. The enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of immunoglobulin G (IgG) and M (IgM) against H. Pylori in patients and controls.Findings: The mean age was 35.8 ± 11.1 and 33.4 ± 18.9 years in patient and control groups, respectively. The mean level of IgM antibody was significantly more in patients (26.3 ± 23.1 U/ml) compared to control group (17.5 ± 11.2 U/ml) (P = 0.004). It was not any significant difference between the levels of IgM and IgG antibodies in patients with MA or MO migraine headache. In addition, the mean HIT6 score was significantly more in patients with MA (65.5 ± 4.7) compared to those with MO (54.9 ± 5.3) migraine headache (P < 0.001). The only significant correlation was found between the IgG antibody level and the HIT6 score in patients with MA (r = 0.407; P = 0.011) and MO (r = 0.499; P = 0.002) migraine headache. There was significant relationship between the normal and high levels of IgG antibody and the severity of headache (P = 0.002) in all the patients. The risk of migraine occurrence in patients was not significantly associated with the levels of IgG and IgM antibodies.Conclusion: Further investigation should be designed to gain better conclusion about the role of H. Pylori treatment and eradication in the course of migraine headaches.
Keywords
Helicobacter pylori
Migraine with aura
Migraine without Aura
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Journal of Isfahan Medical School
Volume 33, Issue 356 - Serial Number 356
September and October 2015
Pages 1796-1803

  • Receive Date 28 December 2014
  • Accept Date 06 April 2022