Journal of Isfahan Medical School

Journal of Isfahan Medical School

The Efficacy of an Innovative Method of Melanocytes-Keratinocytes Suspension for the Treatment of Stable Vitiligo (A Report of 20 Cases)

Document Type : Case Report

Authors
Fariba Jaffary 1
Mohammad Ali Nilforoushzadeh 2
Elaheh Haftbaradaran 3
Azadeh Zolfaghari-Baghbaderani 4
Zahra Mollabashi 4
1 Professor, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Associate Professor, Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran AND Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
3 General Practitioner, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
4 Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Background: Vitiligo is the most common chronic depigmentation disorder caused by melanocyte loss in the basal epidermis. Drug therapy and surgical procedures are two main modalities for its treatment and one of the most effective surgical procedures is non-cultured epidermal cell transplantation suspension containing melanocytes and keratinocytes cells. This pilot study evaluates the effectiveness of an innovative method of melanocyte-keratinocyte cell suspension for treatment of patients with stable vitiligo.Methods: Twenty patients with stable vitiligo which where resistant to standard treatment participated in this study. Melanocyte- keratinocyte cell suspension (with Patent No. 81687 method) was transferred to the affected lesions. Repigmentation of the lesions was scored as excellent, good, fair or weak by comparing lesion photos before and 6 months after the treatment.Findings: Mean repigmentation score was excellent in 1(5%), good in 4(20%), fair in 11(55%) and weak in 4 (20%) of the patients 6 months after the intervention.Conclusion: The results of this study demonstrated that melanocyte-keratinocyte cell suspension can provide good results and repigmentation in more than 50% of cases.
Keywords
Vitiligo
Melanocyte
Keratinocyte
Cell suspension
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Journal of Isfahan Medical School
Volume 34, Issue 370 - Serial Number 370
January and February 2016
Pages 74-79

  • Receive Date 21 November 2015
  • Accept Date 06 April 2022