Evaluation of Anti-Tissue-Trans Glutamines IgA in Alopecia Areata

Document Type : Original Article (s)

Authors

1 Assistant Professor, Skin Diseases and Leishmaniasis Research Center AND Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Professor, Skin Diseases and Leishmaniasis Research Center AND Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Student Of Medicine, School of Medicine AND Student Research Committee, Isfahan University of Medical sciences, Isfahan, Iran

4 Professor, Skin Diseases and Leishmaniasis Research Center AND Department of Biostatics and Epidemiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

5 Associate Professor, Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Background: Alopecia areata (AA) is a common and asymptomatic disease which is characterized by rapid loss of hair in an area. Etiology of the disease is not fully understood. Several studies declare relationship between AA and celiac disease. This study aimed at evaluating the frequency distribution of celiac autoantibodies in patients with AA comparing to the control group.Methods: This study is a case-control study. 35 subjects entered in each group. Anti-tissue-trans-glutaminase IgA (Anti-tTg IgA) were tested in all subjects. And the result was reported as positive/negative. Finally the frequency distribution of these autoantibodies were compared between two groups.Findings: There was no significant difference between two groups based on gender and sex (P = 0.151) and (P = 0.621) respectively, via chi-square test analysis. Anti-tTg IgA was positive in one person (2.8%) In the case group. No one was positive in the control group, and therefor there is no significant difference between two groups (P = 0.314) based on chi-square test. In the case group the most common form of AA was patchy, and the most common nail involvement was Pitting. 17/1% of patients had positive family history of AA.Conclusion: The study shows the frequency distribution of one of the celiac autoantibodies in patients with alopecia areata is not higher than normal population of the community of Isfahan. Therefore screening other autoantibodies such as Anti-Gliadin IgA and Anti-Gliadin IgG in these patients are recommended.

Keywords

References

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Journal of Isfahan Medical School
Volume 34, Issue 379 - Serial Number 379
March and April 2016
Pages 381-386

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History

  • Receive Date: 21 December 2015
  • Revise Date: 27 April 2024
  • Accept Date: 06 April 2022

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