Comparative Evaluation of the Effects of Different Doses of Labetalol on Cardiovascular Response to Tracheal Intubation

Document Type : Original Article (s)

Authors

1 Professor, Department of Anesthesiology, School of Medicine AND Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Student of Medicine, School of Medicine AND Students Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

3 General Practitioner, Isfahan University of Medical Sciences, Isfahan, Iran

4 Representative of Anesthesiology, Kashani Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

AbstractBackground: This study aimed to determine the effects of different doses of labetalol on cardiovascular responses during tracheal intubation and to compare it with control group.Methods: In this study, 180 patients underwent surgery were selected and randomly divided in four groups who received 0.4, 1 and 2 mg/kg labetalol and normal saline via intravenous injection 5 minutes before laryngoscopy, respectively. The changes of hemodynamic parameters in four groups were compared.Findings: During the study, no patients in groups 0.4 and 1 mg/kg labetalol suffered from bradycardia; while in group of 2 mg/kg labetalol, at the time of laryngoscopy and at 1, 3, 5, 10, 30 and 60 minutes after it 13.3, 2.2, 11.1, 37.8, 28.9 and 24.4 percent of patients suffered from bradycardia, respectively; and in control group, 7 patients (15.6%) suffered from bradycardia. The incidence of bradycardia from 5th to 60th minutes was significantly different between the four groups (P < 0.05). No patient suffered from tachycardia among the groups receiving different doses of labetalol; while in control group, at the time of laryngoscopy and 1, 3, 5, and 10 minutes after it, 11.1, 40.0, 31.1, and 20.0 percent of the patients suffered from tachycardia, respectively (P < 0.05).Conclusion: Intravenous injection of 1 mg/kg labetalol during laryngoscopy tends to more favorable hemodynamic stability and minimal bradycardia, tachycardia and hypertension; using this dose before laryngoscopy is more favorable. 

Keywords

References

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Journal of Isfahan Medical School
Volume 34, Issue 393 - Serial Number 393
July and August 2016
Pages 893-900

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History

  • Receive Date: 16 May 2016
  • Revise Date: 06 May 2024
  • Accept Date: 06 April 2022

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