Journal of Isfahan Medical School

Journal of Isfahan Medical School

Evaluating the Relationship of Serum Level of Magnesium at Arrival to Intensive Care Unit and Mortality Rate and Inflamatory Factors in Patients with Multiple Trauma

Document Type : Original Article (s)

Authors
Saeed Abbasi 1
Azim Honarmand 1
Soheila Masoudi 2
Sayyed Amirhossein Mohsenzadeh 2
1 Professor, Department of Anesthesiology, School of Medicine AND Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Student of Medicine, School of Medicine AND Students Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
AbstractBackground: Microelements deficiency in patients with multiple trauma in intensive care units are very important and can lead to severe complications and increased mortality and morbidity rates in these patients. Magnesium has various roles in the body but a few studies demonstrated its relationship with inflammatory factors and their impact on mortality rate in critically ill patients. This study was conducted to evaluate the relation of serum level of magnesium at arrival to intensive care unit and inflammatory factors and mortality rate in patients with multiple trauma.Methods: 80 patients multiple with trauma hospitalized in intensive care unit of Alzahra hospital, Isfahan, Iran, aged 16 to 85 years were included. Serum levels of magnesium, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), interleukin 1 (IL1), interleukin 33 (IL33), and interleukin 6 (IL6) were measured. Acute Physiology and Chronic Health Evaluation II (APACHE II) and Sequential Organ Failure Assessment (SOFA) scores were calculated for each patient. Pearson’s correlation test was used to analysis the relationship between these variables and serum level of magnesium.Findings: All 80 patients were included in final analysis. Mean magnesium level was 33.0 ± 69.1 mg/dl; 46 and 34 patients (57.5 and 42.5 percents) had low and normal levels of magnesium, respectively. Pearson’s correlation test showed lower levels of IL1 and higher levels of platelet, and serum sodium and potassium and bilirubin and longer duration of ventilation in hypomagnesemic patients.Conclusion: There is significant relationship between serum levels of IL1, sodium, bilirubin, and platelet, and duration of ventilation with serum level of magnesium and no relationship between and mortality rate of patients with multiple trauma and serum level of magnesium.
Keywords
Magnesium
Critically ill patient
Mortality
Inflammatory factors
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Journal of Isfahan Medical School
Volume 34, Issue 394 - Serial Number 394
July and August 2016
Pages 919-926

  • Receive Date 16 December 2015
  • Accept Date 06 April 2022