Journal of Isfahan Medical School

Journal of Isfahan Medical School

Association of Relapse of Multiple Sclerosis with Increased Serum Levels of Leptin and Decreased Aerobic Capacity in Women

Document Type : مقاله کوتاه

Authors
Motahareh Mokhtarzadeh 1
Nastaran Majdinasab 2
Raoof Negaresh 1
Rohollah Ranjbar 3
1 MSc Student, Department of Exercise Physiology, School of Physical Education, Shahid Chamran University, Ahvaz, Iran
2 Associate Professor, Musculoskeletal Rehabilitation Research Center AND Department of Neurology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Assistant Professor, Department of Exercise Physiology, School of Physical Education, Shahid Chamran University, Ahvaz, Iran
Abstract
Background: Multiple sclerosis (MS) is a demyelinating autoimmune disease, with an unclear mechanism, and characterized by axonal damage, demyelination and increase inflammatory. Recently, it has been found that leptin plays a role in the pathogenesis of multiple sclerosis. The current study aimed to compare serum level of leptin and aerobic capacity in relapsing and remitting duration in women with multiple sclerosis.Methods: 32 women with multiple sclerosis including 12 in relapsing and 20 in remitting phases participated in this study. Serum level of leptin was assessed using enzyme-linked immunosorbent assay (ELISA) kit and aerobic capacity was measured using ergometer cycle incremental test. Independent t and Pearson correlation tests were used for data analysis at the significant level of P ≤ 0.05.Findings: Data indicated that leptin was higher in relapsing group; but, aerobic capacity was higher in remitting group (P ≤ 0.05). In addition, a negative and significant correlation was observed between leptin and aerobic capacity in both groups and leptin and body mass index in remitting group (P ≤ 0.05).Conclusion: According to the result, increasing of leptin and decreasing of aerobic capacity associated with relapsing in patients with relapsing-remitting multiple sclerosis.
Keywords
Multiple sclerosis (MS)
Leptin
Aerobic capacity
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Journal of Isfahan Medical School
Volume 34, Issue 403 - Serial Number 403
September and October 2016
Pages 1251-1255

  • Receive Date 11 August 2016
  • Accept Date 06 April 2022