Association of Relapse of Multiple Sclerosis with Increased Serum Levels of Leptin and Decreased Aerobic Capacity in Women

Document Type : مقاله کوتاه

Authors

1 MSc Student, Department of Exercise Physiology, School of Physical Education, Shahid Chamran University, Ahvaz, Iran

2 Associate Professor, Musculoskeletal Rehabilitation Research Center AND Department of Neurology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

3 Assistant Professor, Department of Exercise Physiology, School of Physical Education, Shahid Chamran University, Ahvaz, Iran

Abstract

Background: Multiple sclerosis (MS) is a demyelinating autoimmune disease, with an unclear mechanism, and characterized by axonal damage, demyelination and increase inflammatory. Recently, it has been found that leptin plays a role in the pathogenesis of multiple sclerosis. The current study aimed to compare serum level of leptin and aerobic capacity in relapsing and remitting duration in women with multiple sclerosis.Methods: 32 women with multiple sclerosis including 12 in relapsing and 20 in remitting phases participated in this study. Serum level of leptin was assessed using enzyme-linked immunosorbent assay (ELISA) kit and aerobic capacity was measured using ergometer cycle incremental test. Independent t and Pearson correlation tests were used for data analysis at the significant level of P ≤ 0.05.Findings: Data indicated that leptin was higher in relapsing group; but, aerobic capacity was higher in remitting group (P ≤ 0.05). In addition, a negative and significant correlation was observed between leptin and aerobic capacity in both groups and leptin and body mass index in remitting group (P ≤ 0.05).Conclusion: According to the result, increasing of leptin and decreasing of aerobic capacity associated with relapsing in patients with relapsing-remitting multiple sclerosis.

Keywords

References

  1. Styne DM. Childhood and adolescent obesity. Prevalence and significance. Pediatr Clin North Am 2001; 48(4): 823-54, vii.
  2. Zhang Y, Scarpace PJ. The role of leptin in leptin resistance and obesity. Physiol Behav 2006; 88(3): 249-56.
  3. Najmi M, Hajifaraji M, Abd Mishani M. The Effect of adipokines secreted from adipose tissue on immune function in obese subjects. Iran J Nutr Sci Food Technol 2013; 7 (5): 887-96. [In Persian].
  4. Teryaeva NB. Leptin as a Neuroprotector and a central nervous system functional stability factor. Neurosci Behav Physiol 2015; 45(6): 612-8.
  5. Langeskov-Christensen M, Heine M, Kwakkel G, Dalgas U. Aerobic capacity in persons with multiple sclerosis: a systematic review and meta-analysis. Sports Med 2015; 45(6): 905-23.
  6. Storer TW, Davis JA, Caiozzo VJ. Accurate prediction of VO2max in cycle ergometry. Med Sci Sports Exerc 1990; 22(5): 704-12.
  7. Kraszula L, Jasinska A, Eusebio M, Kuna P, Glabinski A, Pietruczuk M. Evaluation of the relationship between leptin, resistin, adiponectin and natural regulatory T cells in relapsing-remitting multiple sclerosis. Neurol Neurochir Pol 2012; 46(1): 22-8.
  8. Correale J, Aguirre MEB, Farez M. Body mass index and multiple sclerosis risk. The role of leptin. Neurology 2014; 82(10 Suppl): S24.004.
  9. Matarese G, Procaccini C, De Rosa V. The intricate interface between immune and metabolic regulation: a role for leptin in the pathogenesis of multiple sclerosis? J Leukoc Biol 2008; 84(4): 893-9.
  10. Procaccini C, Pucino V, Mantzoros CS, Matarese G. Leptin in autoimmune diseases. Metabolism 2015; 64(1): 92-104.
  11. Matarese G, Di Giacomo A, Sanna V, Lord GM, Howard JK, Di Tuoro A, et al. Requirement for leptin in the induction and progression of autoimmune encephalomyelitis. J Immunol 2001; 166(10): 5909-16.
  12. Batocchi AP, Rotondi M, Caggiula M, Frisullo G, Odoardi F, Nociti V, et al. Leptin as a marker of multiple sclerosis activity in patients treated with interferon-beta. J Neuroimmunol 2003; 139(1-2): 150-4.
  13. Frisullo G, Angelucci F, Mirabella M, Caggiula M, Patanella K, Nociti V, et al. Leptin enhances the release of cytokines by peripheral blood mononuclear cells from relapsing multiple sclerosis patients. J Clin Immunol 2004; 24(3): 287-93.
  14. Masoudinejad M, Shirvani H. Effect of selected combined training program on leptin serum level of men with multiple sclerosis. Journal of Exercise Physiology and Physical Activity 2011; 4(1): 545-53. [In Persian].
Journal of Isfahan Medical School
Volume 34, Issue 403 - Serial Number 403
September and October 2016
Pages 1251-1255

Files

History

  • Receive Date: 11 August 2016
  • Revise Date: 06 May 2024
  • Accept Date: 06 April 2022

Share

How to cite

Statistics