The Rate of Birth Asphyxia and its Relationship with Delivery Mode at Shahid Beheshti Hospital, Isfahan City, Iran, during 2013-2015

Document Type : Original Article (s)

Authors

1 Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Assistant Professor, Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Birth asphyxia is still considered as one of the biggest challenges faced by perinatal care experts. According to the statistics published by World Health Organization (WHO) in 2005, it is estimated that one fourth of infant mortality cases occurs due to birth asphyxia.Methods: This cross-sectional retrospective clinical trial study was done on newborn population with gestational ages of 36 weeks or higher, including those afflicted with birth asphyxia, during the years 2013-2015. The relationship between the mode of delivery and the cases of birth asphyxia were investigated using logistic regression test via SPSS software.Findings: Of 13574 newborns, 67 newborns were afflicted with birth asphyxia between the years 2013 to 2015. The rates of birth asphyxia among the newborns in years 2013 and 2014 were less than 0.3%; but, this rate had reached almost 1% in 2015. Meanwhile, the birth asphyxia rate among the vaginal deliveries had doubled in 2015; while the same rate among section deliveries had risen to 5 times more than that of 2013. Logistic regression analysis showed that only one of the independent variables, "year", made a unique statistically significant contribution to the model (P < 0.001). The delivery mode did not have any statistically significant influence on the newborns’ affliction with birth asphyxia (P = 0.993).Conclusion: There was an obvious difference between the prevalence of birth asphyxia in our study and WHO rates. More studies with larger sample sizes in different centers and cities are recommended.

Keywords

References

  1. Lawn JE, Cousens S, Zupan J. 4 million neonatal deaths: when? Where? Why? Lancet 2005; 365(9462): 891-900.
  2. Pierrat V, Haouari N, Liska A, Thomas D, Subtil D, Truffert P. Prevalence, causes, and outcome at 2 years of age of newborn encephalopathy: population based study. Arch Dis Child Fetal Neonatal Ed 2005; 90(3): F257-F261.
  3. Marlow N, Budge H. Prevalence, causes, and outcome at 2 years of age of newborn encephalopathy. Arch Dis Child Fetal Neonatal Ed 2005; 90(3): F193-F194.
  4. Cowan F. Outcome after intrapartum asphyxia in term infants. Semin Neonatol 2000; 5(2): 127-40.
  5. Al-Macki N, Miller SP, Hall N, Shevell M. The spectrum of abnormal neurologic outcomes subsequent to term intrapartum asphyxia. Pediatr Neurol 2009; 41(6): 399-405.
  6. Lei H, Peeling J. Effect of temperature on the kinetics of lactate production and clearance in a rat model of forebrain ischemia. Biochem Cell Biol 1998; 76(2-3): 503-9.
  7. Penrice J, Lorek A, Cady EB, Amess PN, Wylezinska M, Cooper CE, et al. Proton magnetic resonance spectroscopy of the brain during acute hypoxia-ischemia and delayed cerebral energy failure in the newborn piglet. Pediatr Res 1997; 41(6): 795-802.
  8. Lei H, Berthet C, Hirt L, Gruetter R. Evolution of the neurochemical profile after transient focal cerebral ischemia in the mouse brain. J Cereb Blood Flow Metab 2009; 29(4): 811-9.
  9. Pasternak JF, Gorey MT. The syndrome of acute near-total intrauterine asphyxia in the term infant. Pediatr Neurol 1998; 18(5): 391-8.
  10. Alvarez-Diaz A, Hilario E, de Cerio FG, Soler A, Alvarez-Diaz FJ. Hypoxic-ischemic injury in the immature brain--key vascular and cellular players. Neonatology 2007; 92(4): 227-35.
  11. O'Brien FE, Iwata O, Thornton JS, De Vita E, Sellwood MW, Iwata S, et al. Delayed whole-body cooling to 33 or 35 degrees C and the development of impaired energy generation consequential to transient cerebral hypoxia-ischemia in the newborn piglet. Pediatrics 2006; 117(5): 1549-59.
  12. Liu Y, Barks JD, Xu G, Silverstein FS. Topiramate extends the therapeutic window for hypothermia-mediated neuroprotection after stroke in neonatal rats. Stroke 2004; 35(6): 1460-5.
  13. Ma D, Hossain M, Chow A, Arshad M, Battson RM, Sanders RD, et al. Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia. Ann Neurol 2005; 58(2): 182-93.
  14. Jatana M, Singh I, Singh AK, Jenkins D. Combination of systemic hypothermia and N-acetylcysteine attenuates hypoxic-ischemic brain injury in neonatal rats. Pediatr Res 2006; 59(5): 684-9.
  15. Martinez-Biarge M, Diez-Sebastian J, Wusthoff CJ, Mercuri E, Cowan FM. Antepartum and intrapartum factors preceding neonatal hypoxic-ischemic encephalopathy. Pediatrics 2013; 132(4): e952-e959.
  16. Aslam HM, Saleem S, Afzal R, Iqbal U, Saleem SM, Shaikh MWA, et al. Risk factors of birth asphyxia. Ital J Pediatr 2014.
  17. Lee AC, Mullany LC, Tielsch JM, Katz J, Khatry SK, LeClerq SC, et al. Risk factors for neonatal mortality due to birth asphyxia in southern Nepal: a prospective, community-based cohort study. Pediatrics 2008; 121(5): e1381-e1390.
Journal of Isfahan Medical School
Volume 35, Issue 419 - Serial Number 419
January and February 2017
Pages 93-97

Files

History

  • Receive Date: 13 December 2016
  • Revise Date: 27 April 2024
  • Accept Date: 06 April 2022

Share

How to cite

Statistics