Journal of Isfahan Medical School

Journal of Isfahan Medical School

Comparison of the Effects of Remifentanyl-Propofol and Remifentasnyl-Isoflurane on Hemodynamic Variables, Blood Gases, and Blood Glucose among Patients under General Anesthesia

Document Type : Original Article (s)

Authors
Mohammadreza Safavi 1
Azim Honarmand 2
Rokhsareh Hajimohammady
1 Professor, Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Background: This study aimed to compare the effects of remifentanyl-propofol and remifentasnyl-isoflurane on hemodynamic variables, blood gases, and blood glucose among patients under general anesthesia.Methods: In a clinical trial study, 110 patients under neurosurgeries with general anesthesia were selected and randomly divided in to two groups. Continuing of anesthesia in the first and second groups was done by remifentanyl-propofol and remifentasnyl-isoflurane, respectively. The changes of hemodynamic variables, blood gases, and blood glucose were compared between the two groups.Findings: The mean blood glucose level in the first hour was significantly more in remifentanyl-propofol group (114.3 ± 44.5 mg/dl) compared to remifentasnyl-isoflurane group (94.7 ± 26.9 mg/dl) (P = 0.006); the mean blood glucose levels in the second and third hours were significantly more in remifentanyl-propofol group, too (P < 0.001 for both). In addition, mean blood pressure levels was significantly more in remifentanyl-propofol group (P < 0.050 for all); but blood gases analysis did not show any statistically difference between the groups.Conclusion: Using remifentanyl + isoflurane in patients underwent neurosurgery with general anesthesia led to better blood glucose and blood pressure levels and using this compound is recommended.
Keywords
Anesthesia
General
Hemodynamic
Blood gas analysis
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Journal of Isfahan Medical School
Volume 35, Issue 421 - Serial Number 421
January and February 2017
Pages 193-199

  • Receive Date 27 October 2016
  • Accept Date 06 April 2022