Journal of Isfahan Medical School

Journal of Isfahan Medical School

The Aloe Vera Gel Improves Structural Disorders in the Brain of Streptozotocin-Induced Diabetic Male Rats.

Document Type : Original Article (s)

Authors
Mohammad Bahrami-Tapehbur 1
Yazdan Mazaheri 2
Mahmood Khaksary-Mahabady 2
Seyed Reza Fatemi-Tabatabaei 3
Mohammad Reza Tabandeh 4
1 PhD Student, Department of Anatomy and Embryology, School of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
2 Associate Professor, Department of Anatomy and Embryology, School of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
3 Associate Professor, Department of Physiology, School of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
4 Associate Professor, Department of Biochemistry, School of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Abstract
Background: Diabetes mellitus can lead to structural disorders in the brain. Aloe vera has antidiabetic, antioxidant, and neuroprotective effects. This study was designed to evaluate the effects of Aloe vera gel on the morphometric changes in the brain of streptozotocin-induced diabetic rats.Methods: 25 male Wistar rats were randomly divided into 5 groups including: control (normal saline), diabetic (normal saline), Aloe vera gel (400 mg/kg/day; gavage), diabetic + Aloe vera gel (400 mg/kg/day; gavage) and diabetic + Neutral Protamine Hagedorn (NPH) insulin (10 IU/kg/day; subcutaneous). Experimental diabetes was induced by streptozotocin injection (60 mg/kg; intraperitoneal). All groups treated for 8 weeks. At the end of treatment course, the rats' brains were removed intact immediately after sacrifice for morphometric measuring by caliper. Histological brain sections were also prepared to assess morphometry of cerebral cortex and hippocampus via ammonium iron (III) sulfate staining.Findings: Diabetes induction reduced weight and dimensions of brain, and diameters of the hippocampus, and white and gray matter of cerebral cortex compared to the control group after 8 weeks (P < 0.05); while treatment of diabetic rats with Aloe vera gel or insulin significantly decreased the structural alterations of the brain and improved the blood glucose level of diabetic rats (P < 0.05).Conclusion: The results showed that oral administration of Aloe vera gel in diabetic rats improves structural disorders of brain and ameliorates diabetes-induced hyperglycemia.
Keywords
Diabetes Mellitus
Aloe vera
Rats
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Journal of Isfahan Medical School
Volume 35, Issue 422 - Serial Number 422
January and February 2017
Pages 235-242

  • Receive Date 01 January 2017
  • Accept Date 06 April 2022