Evaluation of the Effects of Vitamin E on Prematurity Complications in Premature Neonates

Document Type : Original Article (s)

Authors

1 Assistant Professor, Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, School of Medicine, Isfahan, Iran

2 Associate Professor, Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, School of Medicine, Isfahan, Iran

3 Assistant Professor, Department of Radiology and Imaging, School of Medicine, Isfahan University of Medical Sciences, School of Medicine, Isfahan, Iran

4 Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

5 Assistant Professor, Department of Community Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

6 Pediatrician, Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Prematurity is accompanied with various complications including sepsis, necrotizing enterocolitis (NEC), intraventricular hemorrhage (IVH), and apnea. In current study, we assessed the effects of oral vitamin E on incidence of prematurity complications in premature neonates.Methods: This was a clinical trial study on 76 neonates in Alzahra hospital, Isfahan, Iran, during 2015-2017. Neonates were randomly divided in two age- and sex-matched group. 38 neonates of case group were treated with 10 units of vitamin E through orogastric tube for three days. Control group were treated with distilled water through orogastric tube. Patients in two groups were evaluated in terms of sepsis, NEC and IVH.Findings: In this study, 48.7% of patients were boys. Mean neonates' age and weight was 28.49 ± 1.46 weeks and 1183.02 ± 167.97 g, respectively. Incidence of sepsis (P = 0.77), NEC (P = 0.53), hypotension (P = 0.31), death (P = 0.45), and IVH in 4th (P = 0.30) and 7th (P = 0.20) day of birth was not significantly different between the two groups.Conclusion: Using oral vitamin E did not have statistically significant effect on prevention of sepsis, necrotizing enterocolitis, and intraventricular hemorrhage. Due to more controllable bioavailability of oral vitamin E in comparison to intramuscular and intravenous use of it, and increased risk of sepsis and necrotizing enterocolitis by using high doses of vitamin E in other reports, further studies with different doses of oral vitamin E are recommended.

Keywords

References

  1. Khoshnood Shariat M, Karimi Z, Rezaienejad M, Basiri A, Torkestani F, Saleh Gargari S. Perinatal complications associated with preterm deliveries at 24 to 33 weeks and 6 days gestation. Iran J Reprod Med 2015; 13(11): 697-702.
  2. Volpe JJ. Postnatal sepsis, necrotizing entercolitis, and the critical role of systemic inflammation in white matter injury in premature infants. J Pediatr 2008; 153(2): 160-3.
  3. Procianoy RS, Silveira RC. A influencia do tempo de coleta sobre os niveis de interleucina-6 na sepse neonatal precoce. J Pediatr. 2004; 80(4): 407-10.
  4. Freitas BACd, Leao RT, Gomes A, Siqueira-Batista R. Terapia nutricional e sepse neonatal. Rev Bras Ter Intensiva 2011; 23(5): 492-8.
  5. Tragante CR, Ceccon ME, Falcao MC, Seiti M, Sakita N, Vieira RA. Prevalencia de sepse por bacterias Gram negativas produtoras de beta-lactamase de espectro estendido em Unidade de Cuidados Intensivos Neonata. Rev Paul Pediatr 2008; 26(1): 59-63.
  6. Ballabh P. Intraventricular hemorrhage in premature infants: Mechanism of disease. Pediatr Res 2010; 67(1): 1-8.
  7. Tengerdy RP, Henzerling RH, Brown GL, Mathias MM. Enhancement of the humoral immune response by vitamin E. Int Arch Allergy Appl Immunol 1973; 44(2): 221-32.
  8. Kuperman AA, Kenet G, Papadakis E, Brenner B. Intraventricular hemorrhage in preterm infants: Coagulation perspectives. Semin Thromb Hemost 2011; 37(7): 730-6.
  9. Chiswick M, Gladman G, Sinha S, Toner N, Davies J. Vitamin E supplementation and periventricular hemorrhage in the newborn. Am J Clin Nutr 1991; 53(1 Suppl): 370S-2S.
  10. Dolfin T, Skidmore MB, Fong KW, Hoskins EM, Shennan AT. Incidence, severity, and timing of subependymal and intraventricular hemorrhages in preterm infants born in a perinatal unit as detected by serial real-time ultrasound. Pediatrics 1983; 71(4): 541-6.
  11. Johnson L, Bowen FW, Jr., Abbasi S, Herrmann N, Weston M, Sacks L, et al. Relationship of prolonged pharmacologic serum levels of vitamin E to incidence of sepsis and necrotizing enterocolitis in infants with birth weight 1,500 grams or less. Pediatrics 1985; 75(4): 619-38.
  12. Fish WH, Cohen M, Franzek D, Williams JM, Lemons JA. Effect of intramuscular vitamin E on mortality and intracranial hemorrhage in neonates of 1000 grams or less. Pediatrics 1990; 85(4): 578-84.
  13. Protective effect of vitamin E against intraventricular haemorrhage in premature babies. Br Med J (Clin Res Ed) 1983; 287(6392): 617-8.
  14. Speer ME, Blifeld C, Rudolph AJ, Chadda P, Holbein ME, Hittner HM. Intraventricular hemorrhage and vitamin E in the very low-birth-weight infant: evidence for efficacy of early intramuscular vitamin E administration. Pediatrics 1984; 74(6): 1107-12.
  15. Smith J. RPA Newborn Care Guidelines. Small Baby Protocol [Online]. [cited 2009]; Available from: URL: https://www.slhd.nsw.gov.au/rpa/neonatal/html/docs/small_baby.pdf
Journal of Isfahan Medical School
Volume 35, Issue 446 - Serial Number 446
July and August 2017
Pages 1185-1191

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History

  • Receive Date: 31 August 2017
  • Revise Date: 02 May 2024
  • Accept Date: 06 April 2022

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