Journal of Isfahan Medical School

Journal of Isfahan Medical School

Comparative Trial of Intravenous Dexmedetomidine versus Midazolam Premedication on Quality of Sedation in Upper Gastrointestinal Endoscopy in Children

Document Type : Original Article (s)

Authors
Amir Shafa 1
Anahita Hirmanpour 2
Omid Aghadavoudi 2
Aida Ghasvarian 3
1 Assistant Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Associate Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Background: Upper gastrointestinal endoscopy is one of the most common outpatient diagnostic and therapeutic interventions in children. Present study aimed to compare the sedative effect of intravenous dexmedetomidine premedication versus midazolam in children undergoing upper gastrointestinal endoscopy.Methods: This was a double-blind randomized trial in which 72 patients were allocated in two groups of 36 undergoing premedication with intravenous (IV) midazolam and dexmedetomidine, respectively. Sedation scale, mean arterial pressure, heart rate, recovery time, and respiratory complications were recorded and compared.Findings: Sedation score was significantly higher with midazolam at 15 minutes following injection (P = 0.005), on admission to recovery (P < 0.001), and 30 minutes after admission to recovery (P = 0.001). Recovery time was significantly longer in midazolam premedication (P < 0.001). Respiratory complications were significantly more frequent with midazolam (P = 0.030).Conclusion: Although dexmedetomidine premedication was associated with lower mean arterial pressure and heart rate, intra-operative and recovery sedation scores were significantly higher with midazolam premedication.
Keywords
Endoscopy
Child
Dexmedetomidine
Midazolam
Sedation
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Journal of Isfahan Medical School
Volume 35, Issue 451 - Serial Number 451
September and October 2017
Pages 1418-1423

  • Receive Date 04 August 2017
  • Accept Date 06 April 2022