Journal of Isfahan Medical School

Journal of Isfahan Medical School

The Relationship between Serum Level of High-Sensitivity C-Reactive Protein (hs-CRP) and Residual Renal Function in Patients under Peritoneal Dialysis during One Year

Document Type : Original Article (s)

Authors
Shiva Seirafian 1
Mojgan Mortazavi 1
Azadeh Falahatkar 2
1 Associate Professor, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
10.22122/jims.v35i454.8088
Abstract
Background: Residual renal function helps the part of solute clearance in patients under peritoneal dialysis. Some studies showed that decline in renal function maybe associate with production of inflammatory mediators in these patients. The aim of this study was to assess the relationship between serum level of high-sensitive C-reactive protein (hs-CRP) and residual renal function in patients under peritoneal dialysis during one year.Methods: In this prospective study, residual renal function estimated by determination of renal creatinine clearance (R Clcr) and renal Kt/V (a number used to quantify hemodialysis and peritoneal treatment adequacy). Serum level of hs-CRP and renal creatinine clearance and renal Kt/V was measured at baseline, and 6 and 12 month after start of study and changes of these parameters during the year and their relationship with together were studied.Findings: Among 96 patients, we did not lose any patients for final analysis. Mean serum level of hs-CRP at baseline, and 6 and 12 months later was 3.585, 4.205, and 4.738 mg/l, respectively. Mean renal creatinine clearance was 58.186, 37.054, 36.299 ml/minute at baseline, and 6 and 12 months later, respectively. Mean renal Kt/V at baseline, and 6 and 12 months later was 3.627, 1.813 and 0.841, respectively.Conclusion: Finally, our statistical analysis showed the negative relationship between changes of serum level of hs-CRP and residual renal function in patients under peritoneal dialysis during one year; but, this relationship was not significant.
Keywords
Peritoneal dialysis
Renal Failure
C-Reactive Protein
Creatinine
Urea
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Journal of Isfahan Medical School
Volume 35, Issue 454 - Serial Number 454
September and October 2018
Pages 1572-1578

  • Receive Date 24 April 2017
  • Accept Date 06 April 2022