Journal of Isfahan Medical School

Journal of Isfahan Medical School

Comparative Controlled Study of Preventive Effect of Combinations of Ketamine and Metoclopramide vs Ketamine and Paracetamol on Postoperative Pain

Document Type : Original Article (s)

Authors
Sayed Morteza Heidari 1
Zohre Zamani-Alavijeh 2
1 Professor, Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
10.22122/jims.v35i456.8408
Abstract
Background: In this study, we compared the effects combinations of ketamine and paracetamol with ketamine and metoclopramide on postoperative pain and their effects on surgical complications. Then, better method for reducing pain and complications was referenced.Methods: In a clinical trial study, 102 candidates for laparoscopic surgery under general anesthesia divided into three equal groups of ketamine and metoclopramide, ketamine and paracetamol, and control. In the first group, 0.5 mg/kg ketamine and 0.1 mg/kg metoclopramide, in the second group, 0.5 mg/kg ketamine and 1 g paracetamol, and in the third group, normal saline were injected. Patients’ systolic and diastolic blood pressures and heart rates in all three groups were measured and recorded every 15 minutes. Then, the effects of these two drug combinations on postoperative pain and some other complications were studied and compared between the three groups.Findings: Average pain intensity was significantly different among the three treated groups (P < 0.05 for all). 2 and 6 hours after the surgery, pain in the group receiving ketamine and paracetamol was significantly lower than the other two groups (P < 0.05). 12 and 24 hours after the surgery, pain was significantly lower than control group just in the group receiving ketamine and paracetamol (P < 0.05).Conclusion: Combination of ketamine and paracetamol is more favorable because of significant decrease in postoperative pain.
Keywords
Ketamine
Metoclopramide
Paracetamol
Postoperative pain
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Journal of Isfahan Medical School
Volume 35, Issue 456 - Serial Number 456
September and October 2018
Pages 1683-1689

  • Receive Date 19 June 2017
  • Accept Date 06 April 2022