The Impact of Preemptive Intramuscular Methadone or Piroxicam in Controlling Pain after Lower Limb Orthopedic Surgery under General Anesthesia

Document Type : Original Article (s)

Authors

1 Associate Professor, Anesthesiology and Critical Care Research Center AND Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Assistant Professor, Anesthesiology and Critical Care Research Center AND Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: This research was conducted to investigate the impact of preemptive intramuscular methadone or piroxicam in controlling pain after lower limb orthopedic surgery under general anesthesia.Methods: This randomized clinical trial study was carried out on 94 patients undergoing lower limb orthopedic surgery, in three groups. In the first group, 20 mg piroxicam was intramuscularly injected into the patient's deltoid muscle after anesthesia and before surgery. In the second group, 0.15 mg/kg intramuscular methadone was injected into the patient's deltoid muscle; and in the third group, the same volume of normal saline was injected intramuscularly. Then, the pain intensity in all three groups were evaluated and recorded using visual analog scale (VAS) in recovery and ward up to 24 hours. Additionally, information such as systolic, diastolic, and mean arterial pressure, and saturated oxygen percentage was recorded during the surgery. Finally, the collected data were analyzed using SPSS software.Findings: The intensity of pain 30 minutes after the surgery in the piroxicam group with a mean of 1.90 ± 0.36 was significantly higher than methadone group with a mean of 0.20 ± 0.17 and both groups received the drug showed significant difference with control group (P < 0.05 for all). In contrast, since 60 minutes later to discharge time from recovery room and in the ward, after 4 to 24 hours, the pain score did not differ significantly between the three groups (P > 0.05 for all).Conclusion: Methadone has an early preventive impact on pain intensity reduction compared to piroxicam, while multiplicity of side effects associated with the use of methadone was more than piroxicam. Finally, pain severity was evaluated equal in two groups for up to 24 hours after the surgery.

Keywords

References

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Journal of Isfahan Medical School
Volume 35, Issue 459 - Serial Number 459
November and December 2018
Pages 1767-1774

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History

  • Receive Date: 22 September 2017
  • Revise Date: 03 May 2024
  • Accept Date: 06 April 2022

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