Evaluation of Clinical Manifestations, Complications, and Disease Course in Children Admitted with Henoch-Schonlein Purpura in Imam Hossain Hospital, Isfahan, Iran, during 2011-2014

Document Type : Original Article (s)

Authors

1 Assistant Professor, Department of Pediatrics, School of Medicine AND Research Institute for Primary Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

2 Assistant Professor, Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: Henoch-Schonlein purpura (HSP) is a common childhood systemic vasculitis with clinical characteristics of cutaneous palpable purpura, arthralgia/arthritis, abdominal pain, and renal involvement. The diagnosis of Henoch-Schonlein purpura is usually based upon clinical manifestations of the disease; but, clinical manifestations are different in various countries. We aimed to find the frequency of clinical manifestations of this disease in Iran.Methods: A retrospective study was performed on children discharged with diagnosis of Henoch-Schonlein purpura from Imam Hossain Children's Hospital, Isfahan, Iran, during 2011 to 2014. Symptoms, signs, laboratory data, treatment, and outcomes were collected via reviewing medical charts.Findings: The sample consisted of 106 children. There was a male predominance with male-to-female ratios of 2.1:1 and the mean age was 5.7 ± 0.5 years. Clinical manifestation of purpura was present in 100%, arthritis/arthralgia in 76%, abdominal pain in 62%, fever in 30%, renal involvement in 29%, gastrointestinal tract bleeding (GIB) in 22%, scrotal edema in 11%, and intussusception in 1.8% of the cases. The most frequent laboratory abnormalities consisted of high erythrocyte sedimentation rate (ESR) in 100%, and C-reactive protein (CRP) in 58 % of the cases.Conclusion: Our findings indicate that there are higher incidences of abdominal pain, gastrointestinal tract bleeding, and intussusception in our sample compared to other studies.

Keywords

References

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Journal of Isfahan Medical School
Volume 35, Issue 461 - Serial Number 461
November and December 2018
Pages 1840-1844

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History

  • Receive Date: 10 December 2016
  • Revise Date: 06 May 2024
  • Accept Date: 06 April 2022

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