The Correlation between Endoscopic and Histological Findings of Esophageal and Gastric Biopsies in Pediatric Patients Referred to Imam Hussein Hospital, Isfahan, Iran, during the Years 2014 to 2015

Document Type : Original Article (s)

Authors

1 Assistant Professor, Department of Pathology, Imam Hussein Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

2 Professor, Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Student of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: The aim of this study was to evaluate the correlation between endoscopic and histological findings of esophageal and gastric biopsies in patients referred to Imam Hussein hospital, Isfahan, Iran, during the years 2014-2015.Methods: In this retrospective study, the endoscopic and histological findings of 243 patients were collected, and classified using the site of biopsy (esophageal or gastric) and the diagnostic findings (eosinophilic esophagitis, esophagitis and ulcer in esophagus, gastritis, nodularity, and gastric follicle and erosion). The age range of the enrolled patients was 1 month to 16 years. In order to find the correlation between endoscopic and histological findings, chi-square, t, and one-way ANOVA tests were performed using SPSS software.Findings: For the esophagus, the positive endoscopic and histologic findings were 117 (48.1%) and 86 (35.4%) cases, respectively. While, for the stomach the positive endoscopic and histologic findings were 157 (64.6%) and 145 (59.7%) cases, respectively. The sensitivity and specificity of the esophagus endoscopic findings were 73.3% and 51.3%, respectively [Area under curve (AUC) = 0.623; P = 0.002]. There were also significant for the stomach findings (AUC = 0.576; P = 0.043).Conclusion: Concordance between endoscopic and histologic findings of the esophagus was stronger compared to the stomach.

Keywords

References

  1. Saito T, Kurokawa Y, Takiguchi S, Mori M, Doki Y. Current status of function-preserving surgery for gastric cancer. World J Gastroenterol 2014; 20(46): 17297-304.
  2. Sheiko MA, Feinstein JA, Capocelli KE, Kramer RE. Diagnostic yield of EGD in children: a retrospective single-center study of 1000 cases. Gastrointest Endosc 2013; 78(1): 47-54.
  3. Ben-Menachem T, Decker GA, Early DS, Evans J, Fanelli RD, Fisher DA, et al. Adverse events of upper GI endoscopy. Gastrointest Endosc 2012; 76(4): 707-18.
  4. Sheiko MA, Feinstein JA, Capocelli KE, Kramer RE. The concordance of endoscopic and histologic findings of 1000 pediatric EGDs. Gastrointest Endosc 2015; 81(6): 1385-91.
  5. Garg B, Sandhu V, Sood N, Sood A, Malhotra V. Histopathological analysis of chronic gastritis and correlation of pathological features with each other and with endoscopic findings. Pol J Pathol 2012; 63(3): 172-8.
  6. Gilis-Januszewska A, Baczycska E, Szybinski P, Hubalewska-Dydejczyk A. Current opinions on pathogenesis, diagnostic procedures and management of gastric neuroendocrine tumors. Przeglad lekarski 2009; 66(12): 1052-61.
  7. Kominami Y, Yoshida S, Tanaka S, Sanomura Y, Hirakawa T, Raytchev B, et al. Computer-aided diagnosis of colorectal polyp histology by using a real-time image recognition system and narrow-band imaging magnifying colonoscopy. Gastrointest Endosc 2016; 83(3): 643-9.
  8. Oderda G, Ansaldi N. Comparison of suction capsule and endoscopic biopsy of small bowel mucosa. Gastrointest Endosc 1987; 33(3): 265-6.
  9. Oderda G, Forni M, Farina L, Dell'Olio D, Ansaldi N. Duodenitis in children: clinical, endoscopic, and pathological aspects. Gastrointest Endosc 1987; 33(5): 366-9.
  10. Wolf EM, Plieschnegger W, Geppert M, Wigginghaus B, Hoss GM, Eherer A, et al. Changing prevalence patterns in endoscopic and histological diagnosis of gastritis? Data from a cross-sectional Central European multicentre study. Dig Liver Dis 2014; 46(5): 412-8.
  11. Black DD, Haggitt RC, Whitington PF. Gastroduodenal endoscopic-histologic correlation in pediatric patients. J Pediatr Gastroenterol Nutr 1988; 7(3): 353-8.
  12. Gilger MA, Gold BD. Pediatric endoscopy: new information from the PEDS-CORI project. Curr Gastroenterol Rep 2005; 7(3): 234-9.
  13. Israel DA, Peek RM, Jr. The role of persistence in Helicobacter pylori pathogenesis. Curr Opin Gastroenterol 2006; 22(1): 3-7.
  14. Parry WH, Martorano F, Cotton EK. Management of life-threatening asthma with intravenous isoproterenol infusions. Am J Dis Child 1976; 130(1): 39-42.
  15. Ament ME, Christie DL. Upper gastrointestinal fiberoptic endoscopy in pediatric patients. Gastroenterology 1977; 72(6): 1244-8.
  16. Carr NJ, Leadbetter H, Marriott A. Correlation between the endoscopic and histologic diagnosis of gastritis. Ann Diagn Pathol 2012; 16(1): 13-5.
  17. Dahshan A, Rabah R. Correlation of endoscopy and histology in the gastroesophageal mucosa in children: are routine biopsies justified? J Clin Gastroenterol 2000; 31(3): 213-6.
Journal of Isfahan Medical School
Volume 36, Issue 481 - Serial Number 481
May and June 2018
Pages 588-593

Files

History

  • Receive Date: 14 October 2017
  • Revise Date: 02 May 2024
  • Accept Date: 06 April 2022

Share

How to cite

Statistics