Journal of Isfahan Medical School

Journal of Isfahan Medical School

The Association between Neutrophil to Lymphocyte Ratio (NLR) and the Extent of Coronary Artery Stenosis in Patients with Non-ST Elevation-Acute Coronary Syndrome (NSTE-ACS)

Document Type : Original Article (s)

Authors
Azam Soleimani 1
Nazgol Aghazadeh-Tabrizi 2
Ali Pourmoghadas 3
1 Assistant Professor, Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
2 Student of Medicine, Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
3 Associate Professor, Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
10.22122/jims.v36i483.10016
Abstract
Background: Cardiovascular diseases are the leading cause of mortality in Iran and in the world. Considering the importance of inflammation in atherosclerosis, studying inflammatory factors and their contribution to cardiovascular diseases is essential. Accordingly, this study evaluated the link between neutrophil to lymphocyte ratio (NLR) and coronary artery stenosis in patients undergoing coronary angiography.Methods: This cross-sectional study was performed on 372 patients under coronary angiography due to non-ST elevation-acute coronary syndrome (NSTE-ACS). In addition to demographic characteristics, neutrophil to lymphocyte ratio and the extent of coronary artery disease (CAD) were measured in patients. Chi-square and ANOVA tests were used to compare the data.Findings: There was a direct and significant association between neutrophil to lymphocyte ratio and the extent of coronary artery disease involvement (r = 0.125, P = 0.016). Moreover, by examining the diagnosis accuracy of the neutrophil to lymphocyte ratio in coronary artery disease, it was found that the best cut-off point was 2.4, the area under curve (ROC) was 0.69, with sensitivity of 72.4% and specificity of 58.3%.Conclusion: Neutrophil to lymphocyte ratio is directly and significantly associated to the extent of involvement of coronary arteries, and it can be used to predict the involvement and extent of coronary artery disease.
Keywords
Neutrophils
Lymphocytes
Coronary Angiography
Coronary Artery Disease
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Journal of Isfahan Medical School
Volume 36, Issue 483 - Serial Number 483
May and June 2018
Pages 644-650

  • Receive Date 25 April 2018
  • Accept Date 06 April 2022