The Effect of Garlic Pills on the Results of Cultured Samples from Peripheral, Urinary, and Central Catheters and Inflammatory Factors in Patients in Intensive Care Unit (ICU)

Document Type : Original Article (s)

Authors

1 Associate Professor, Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

2 Fellowship Resident of Critical Care, Department of Anesthesiology and , School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Background: The aim of this study was to determine the effect of garlic oral pill in preventing the onset of nosocomial infection in the patients who admitted in intensive care unit (ICU).Methods: In a clinical trial study, 100 patients who admitted in intensive care unit of Alzahra hospital, Isfahan, Iran, were selected and randomly divided into two groups. The first group were received garlic tablets every 8 hours for 6 days, and the second group did not receive the garlic pill. During the study, inflammatory factors, sepsis, and infection were compared between the two groups.Findings: 78 samples of intravenous catheter were sent to the laboratory for culture, 37 of which were in the intervention group and 41 were in the control group. The result of the culture of the tip of the venous catheter was positive in 5 cases, all of which were in the control group, and no positive culture was observed in the intervention group (P = 0.035). For 35 patients in the intervention group and 30 in the control group, urine culture was performed. The results of the culture were positive in two of the intervention group and six in the control group (5.7% versus 20%), but the difference was not significant (P = 0.130).Conclusion: The use of garlic pill in patients admitted in intensive care units that are highly susceptible to hospital infection may be effective in preventing septicemia and urinary tract infections.

Keywords

References

  1. Irwin RS, Rippe JM. Manual of intensive care medicine. 6th ed. Philadelphia, PA: Lippincott Williams and Wilkins; 2013. p. 440-70.
  2. Ducel G, Fabry J, Nicolle L. Prevention of hospital-acquired infections: A practical guide. Geneva, Switzerland: World Health Organization; 2008. p. 15.
  3. Gaynes R, Edwards JR. Overview of nosocomial infections caused by gram-negative bacilli. Clin Infect Dis 2005; 41(6): 848-54.
  4. Gastmeier P, Geffers C, Schwab F, Fitzner J, Obladen M, Ruden H. Development of a surveillance system for nosocomial infections: The component for neonatal intensive care units in Germany. J Hosp Infect 2004; 57(2): 126-31.
  5. Flanders SA, Collard HR, Saint S. Nosocomial pneumonia: State of the science. Am J Infect Control 2006; 34(2): 84-93.
  6. Kaoutar B, Joly C, L'Heriteau F, Barbut F, Robert J, Denis M, et al. Nosocomial infections and hospital mortality: A multicentre epidemiology study. J Hosp Infect 2004; 58(4): 268-75.
  7. Jeong SH, Bae IK, Kwon SB, Lee K, Yong D, Woo GJ, et al. Investigation of a nosocomial outbreak of Acinetobacter baumannii producing PER-1 extended-spectrum beta-lactamase in an intensive care unit. J Hosp Infect 2005; 59(3): 242-8.
  8. Zolldann D, Haefner H, Poetter C, Buzello S, Sohr D, Luetticken R, et al. Assessment of a selective surveillance method for detecting nosocomial infections in patients in the intensive care department. Am J Infect Control 2003; 31(5): 261-5.
  9. Shams Ghahfarokhi M, Razafsha M, Allameh A, Razzaghi Abyaneh M. inhibitory effects of aqueous onion and garlic extracts on growth and keratinase activity in Trichophyton mentagrophytes. IBJ 2003; 7(3): 113-8.
  10. El-Demerdash FM, Yousef MI, El-Naga NI. Biochemical study on the hypoglycemic effects of onion and garlic in alloxan-induced diabetic rats. Food Chem Toxicol 2005; 43(1): 57-63.
  11. Fugh-Berman A, Ernst E. Herb-drug interactions: review and assessment of report reliability. Br J Clin Pharmacol 2001; 52(5): 587-95.
  12. Ernst E. Garlic therapy? Theories of a folk remedy (author's transl). MMW Munch Med Wochenschr 1981; 123(41): 1537-8. [In German].
  13. Bordia A, Bansal HC, Arora SK, Singh SV. Effect of the essential oils of garlic and onion on alimentary hyperlipemia. Atherosclerosis 1975; 21(1): 15-9.
  14. Dulger B, Gonuz A. Antimicrobial activity of certain plants used in Turkish traditional medicine. Asian J Plant Sci 2004; 3(1): 104-7.
  15. Dikasso D, Lemma H, Urga K, Debella A, Addis G, Tadele A, et al. Investigation on the antibacterial properties of garlic (Allium sativum) on pneumonia causing bacteria. Ethiop Med J 2002; 40(3): 241-9.
  16. Josling P. Preventing the common cold with a garlic supplement: A double-blind, placebo-controlled survey. Adv Ther 2001; 18(4): 189-93.
  17. Elnima EI, Ahmed SA, Mekkawi AG, Mossa JS. The antimicrobial activity of garlic and onion extracts. Pharmazie 1983; 38(11): 747-8.
  18. Alice D, Sivaprakasam K. Antibiotics and garlic clove extract--inhibitory agents of cell wall degrading enzymes. Hindustan Antibiot Bull 1995; 37(1-4): 44-7.
Journal of Isfahan Medical School
Volume 36, Issue 485 - Serial Number 485
May and June 2018
Pages 698-704

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History

  • Receive Date: 15 January 2018
  • Revise Date: 09 November 2024
  • Accept Date: 06 April 2022

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