Journal of Isfahan Medical School

Journal of Isfahan Medical School

The Effect of Topical Tranexamic Acid versus Injection into the Clamped Drain on Postsurgical Bleeding in Knee Arthroplasty Surgery: A Double-Blind Randomized Clinical Trial Study

Document Type : Original Article (s)

Authors
Seyed Mohammad Jalil Abrisham 1
Mohammad reza Sobhan 1
Ehsan Golkar-Khouzani 2
Seyed Ali Sonbolestan 3
1 Associate Professor, Department of Orthopedic Surgery, School of Medicine, Yazd University of Medical Sciences, Yazd, Iran
2 Resident, Department of Orthopedic Surgery, School of Medicine, Yazd University of Medical Sciences, Yazd, Iran
3 General Practitioner, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
10.22122/jims.v36i499.10384
Abstract
Background: Knee arthroplasty is one of the most effective treatments in osteoarthritis. However, postsurgical bleeding, followed by blood transfusion, is one of the important complications. This study aimed to compare the effect of topical versus injection of tranexamic acid into the clamped drain on postsurgical bleeding in knee arthroplasty surgery.Methods: In this double-blinded clinical trial study, patients with primary osteoarthritis were randomly divided into three groups to receive placebo injection into the drain clamp, tranexamic acid injection into the drain, and topical tranexamic acid, respectively. Demographic data, as well as hemoglobin level before surgery, and 12 and 48 hours after it were recorded. Data analysis was done using chi-square, ANOVA, and t tests via SPSS software.Findings: 75 patients (67 women and 8 men) with mean age of 63.26 ± 5.15 years were enrolled. Mean hemoglobin level was 13.29 ± 1.23 g/dl before the surgery and did not have any difference between the three groups (P = 0.891). Considering the level of hemoglobin after 48 hours, it decreased significantly more in group of tranexamic acid injection into the clamped drain compared to other groups (P = 0.001).Conclusion: Topical and injection into the clamped drain of tranexamic acid could be effective in reducing the need for blood transfusion and the degree of anemia in patients undergoing knee arthroplasty surgery, but the difference was not significant in this study.
Keywords
Tranexamic acid
Arthroplasty
Knee
Hemorrhage
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Journal of Isfahan Medical School
Volume 36, Issue 499 - Serial Number 499
September and October 2018
Pages 1206-1212

  • Receive Date 02 July 2018
  • Accept Date 06 April 2022